2023
DOI: 10.3389/fphar.2023.1107507
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Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling

Abstract: Introduction: Sleep disorders are common clinical psychosomatic disorders that can co-exist with a variety of conditions. In humans and animal models, sleep deprivation (SD) is closely related with gastrointestinal diseases. Shu-Xie Decoction (SX) is a traditional Chinese medicine (TCM) with anti-nociceptive, anti-inflammatory, and antidepressant properties. SX is effective in the clinic for treating patients with abnormal sleep and/or gastrointestinal disorders, but the underlying mechanisms are not known. Th… Show more

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Cited by 4 publications
(2 citation statements)
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“…During the short-term or acute state of oxidative stress, the expression and activity of Nrf2 may increase to enhance the cell's antioxidant defense. [30,31] However, in the long-term chronic state of oxidative stress, changes in the expression and activity of Nrf2 and Keap1 may be more complex. Some studies suggest that prolonged stress may lead to the depletion of Nrf2 function or the enhancement of Keap1 function, resulting in a reduction of the cell's antioxidant defense.…”
Section: Discussionmentioning
confidence: 99%
“…During the short-term or acute state of oxidative stress, the expression and activity of Nrf2 may increase to enhance the cell's antioxidant defense. [30,31] However, in the long-term chronic state of oxidative stress, changes in the expression and activity of Nrf2 and Keap1 may be more complex. Some studies suggest that prolonged stress may lead to the depletion of Nrf2 function or the enhancement of Keap1 function, resulting in a reduction of the cell's antioxidant defense.…”
Section: Discussionmentioning
confidence: 99%
“…A crucial regulator of cellular ROS levels and oxidative stress responses is the Kelch-like ECH-associated protein 1 [47]. As an adapter protein, Kelch-like ECH-associated protein 1 interacts with nuclear factor erythroid 2-related factor 2 to function [45].…”
Section: Figurementioning
confidence: 99%