In this work, we prove the existence, uniqueness and smoothing properties of the solution to the Cauchy problem for the spatially homogeneous Boltzmann equation with Debye-Yukawa potential for probability measure initial datum.Without loss of generality, we may assume that B(v−v * , σ) is supported on the set cos θ ≥ 0, i.e. where 0 ≤ θ ≤ π 2 . See for example [19] for more explanations about the support of θ. For physical models, the collision cross section usually takes the form B(v − v * , σ) = Φ(|v − v * |)b(cos θ).