Shunt ascites in a fourth ventricular choroid plexus papilloma in a young child: An uncommon case

Bansal, Sumit; Satapathy, Amit Kumar; Purkait, Suvendu; Sahu, Rabi Narayan

doi:10.4103/jpn.jpn_69_19

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…Our results demonstrate that ChP gets larger with the progression of AD, which is in line with the previous study [5]. Since the ChP volume was found to be related to the CSF production [25,26], a larger ChP volume may indicate increased CSF secretion, which is used to clean the brain metabolism waste through the glymphatic system. This assumption can be further supported by the higher ChP perfusion in the AD.…”

Section: Discussionsupporting

confidence: 92%

Associations between the Choroid Plexus and Tau in Alzheimer’s Disease using an Active Learning Segmentation Pipeline

Li,

Hu,

et al. 2024

Preprint

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Background The cerebrospinal fluid (CSF), primarily generated by the choroid plexus (ChP), is the major carrier of the glymphatic system. The alternations of CSF production and the ChP can be associated with the Alzheimer's disease (AD). The present work investigated the roles of the ChP in the AD based on a proposed ChP image segmentation pipeline. Methods A human-in-the-loop ChP image segmentation pipeline was implemented with intermediate and active learning datasets. The performance of the proposed pipeline was evaluated on manual contours by five radiologists, compared to the FreeSurfer and FastSurfer toolboxes. The ChP volume and blood flow were investigated among AD groups. The correlations between the ChP volume and AD CSF biomarkers including p-tau, t-tau, Aβ42, and Aβ40 was investigated using three models (univariate, multiple variables, and stepwise regression) on two datasets with 806 and 320 subjects. Results The proposed ChP segmentation pipeline achieved superior accuracy with 27.8% and 24.9% higher Dice coefficient compared to the FreeSurfer and FastSurfer. Significantly larger volumes (p < 0.001) and higher perfusion (p = 0.032) at the ChP were found in AD compared to CN groups. Significant correlations were found between the tau and the relative ChP volume (the ChP volume and ChP/parenchyma ratio) in each patient groups and in the univariate regression analysis (p < 0.001), the multiple regression model (p < 0.05 except for the t-tau in the LMCI), and in the step-wise regression model (p < 0.021). In addition, the correlation coefficients reduced from − 0.32 to -0.21 along with the AD progression in the multiple regression model. In contrast, the Aβ42 and Aβ40 shows consistent and significant associations with the lateral ventricle related measures in the step-wise regression model (p < 0.027). Conclusions The proposed pipeline provided accurate ChP segmentation which revealed the associations between the ChP and tau level in the AD. The proposed pipeline is available on github://xxxx.

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Section: Discussionsupporting

confidence: 92%

Associations between the Choroid Plexus and Tau in Alzheimer’s Disease using an Active Learning Segmentation Pipeline

Li,

Hu,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Associations between the choroid plexus and tau in Alzheimer’s disease using an active learning segmentation pipeline

Li,

Hu,

et al. 2024

Fluids Barriers CNS

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Background The cerebrospinal fluid (CSF), primarily generated by the choroid plexus (ChP), is the major carrier of the glymphatic system. The alternations of CSF production and the ChP can be associated with the Alzheimer’s disease (AD). The present work investigated the roles of the ChP in the AD based on a proposed ChP image segmentation pipeline. Methods A human-in-the-loop ChP image segmentation pipeline was implemented with intermediate and active learning datasets. The performance of the proposed pipeline was evaluated on manual contours by five radiologists, compared to the FreeSurfer and FastSurfer toolboxes. The ChP volume and blood flow were investigated among AD groups. The correlations between the ChP volume and AD CSF biomarkers including phosphorylated tau (p-tau), total tau (t-tau), amyloid-β42 (Aβ42), and amyloid-β40 (Aβ40) was investigated using three models (univariate, multiple variables, and stepwise regression) on two datasets with 806 and 320 subjects. Results The proposed ChP segmentation pipeline achieved superior performance with a Dice coefficient of 0.620 on the test dataset, compared to the FreeSurfer (0.342) and FastSurfer (0.371). Significantly larger volumes (p < 0.001) and higher perfusion (p = 0.032) at the ChP were found in AD compared to CN groups. Significant correlations were found between the tau and the relative ChP volume (the ChP volume and ChP/parenchyma ratio) in each patient groups and in the univariate regression analysis (p < 0.001), the multiple regression model (p < 0.05 except for the t-tau in the LMCI), and in the step-wise regression model (p < 0.021). In addition, the correlation coefficients changed from − 0.32 to − 0.21 along with the AD progression in the multiple regression model. In contrast, the Aβ42 and Aβ40 shows consistent and significant associations with the lateral ventricle related measures in the step-wise regression model (p < 0.027). Conclusions The proposed pipeline provided accurate ChP segmentation which revealed the associations between the ChP and tau level in the AD. The proposed pipeline is available on GitHub (https://github.com/princeleeee/ChP-Seg).

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Shunt ascites in a fourth ventricular choroid plexus papilloma in a young child: An uncommon case

Cited by 2 publications

References 4 publications

Associations between the Choroid Plexus and Tau in Alzheimer’s Disease using an Active Learning Segmentation Pipeline

Associations between the Choroid Plexus and Tau in Alzheimer’s Disease using an Active Learning Segmentation Pipeline

Associations between the choroid plexus and tau in Alzheimer’s disease using an active learning segmentation pipeline

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