1971
DOI: 10.1212/wnl.21.1.26
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Shy‐Drager syndrome

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Cited by 26 publications
(5 citation statements)
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“…As in out case the daily excretion of total catecholamines was repeatedly found to be normal (Sharpe et al 1972;Thapedi et al 1971). In contrast to our results, Bannister et al (1977) reported decreased basal plasma levels for noradrenaline in the Shy-Drager syndrome.…”
Section: Discussioncontrasting
confidence: 71%
See 1 more Smart Citation
“…As in out case the daily excretion of total catecholamines was repeatedly found to be normal (Sharpe et al 1972;Thapedi et al 1971). In contrast to our results, Bannister et al (1977) reported decreased basal plasma levels for noradrenaline in the Shy-Drager syndrome.…”
Section: Discussioncontrasting
confidence: 71%
“…Several authors (Luft and Euler 1953;Goodall et al 1967;Hedeland et al 1969;Anlauf et al 1975) reported a decreased urinary output of catecholamines. Routine assays, however, of ten fail to detect a reduction of urinary catecholamines (Sharpe et al 1972;Thapedi et al 1971). Since plasma catecholamines may be a better index for an altered secretion rate we tested plasma catecholamines of a patient with a weil documented Shy-Drager syndrome before and after stimulation of the sympathetic nervous system by postural change and physical activity.…”
Section: Introductionmentioning
confidence: 99%
“…The ANS deficit in Parkinson's disease, an idio pathic degenerative disease of selective brain areas which has many characteristics in com mon with DAT, is well known [4,21]. In Parkinson's disease, the basis of the ANS deficit is thought to be a degeneration of the dorsal nucleus of the vagus and locus ceruleus, both noradrenergic nuclei [12], Degen eration of these two nuclei is also a common finding in autopsies of patients with ShyDrager syndrome [3,28], which is a typical degenerative disease of ANS. Early presenile onset and a progressive development of the dementia, such as observed in our patients, seems to be related to more severe damage of septal nuclei, specifically the nucleus basalis of Meynert and the locus ceruleus [22].…”
Section: Discussionmentioning
confidence: 99%
“…The pathological picture of dysautonomia syndromes is variable. In Shy-Drager syndrome, changes are found in the intermediolateral columns of the spinal cord and in the brainstem [42,45,47], whereas in familial dysautonomia the abnormalities involve the sympathetic and sensory ganglia and the peripheral nerves [37, 381. Other cases of dysautonomia are associated with diabetes mellitus, amyloidosis, botulism, generalized neuropathy, neoplasms, Parkinson's disease, and spinal cord lesions [2,?, 12, 18,24, 261. To the best of our knowledge there is no pub- [34] or cases occurring after cervical cordotomy [ 2 11 or bulbar poliomyelitis [ 141.…”
Section: Discussionmentioning
confidence: 99%