Abstract:RhD is a clinically important blood group and a major target in haemolytic disease of the newborn (HDN). Current anti‐D antibody therapy to prevent antibody production in RhD negative mothers is ineffective if there has already been sensitization. Peptide immunotherapy offers an alternative approach. Helper T cell epitopes of the RhD antigen were previously identified in alloimmunized donors and we have shown that instillation of these immunodominant RhD‐specific peptides to the nasal mucosa of DR transgenic m… Show more
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