SIADH is only an Atypical Clinical Feature in a Patient with Prolactinoma

Saito, T.; Watanabe, Yasutaka; Yuzawa, Miho; Saitô, Takako; Tamemoto, Hiroyuki; Suzuki, Hisashi; Kusaka, Gen; Omori, Yoshio; Shinoda, Souji; Kawakami, Masanobu; Ishikawa, San‐e

doi:10.2169/internalmedicine.46.6422

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…SIADH rarely occurs in patients with sellar lesions and is usually due to compression and dislocation of the stalk [7][8][9][10][11][12][13][14]. In this study, we document a unique case of SNB presenting with SIADH due to ectopic production of antidiuretic hormone (ADH) in neoplastic cells.…”

Section: Introductionmentioning

confidence: 95%

Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone

et al. 2010

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A 29-year-old Ethiopian man presented with marked bilateral visual loss, headache, hypopituitarism and significant hyponatraemia (115 mmol/L). A brain MRI scan demonstrated a large, lobulated, sellar and suprasellar mass, elevating the floor of the 3rd ventricle and compressing the optic chiasm. The patient underwent a transphenoidal resection of the mass followed by a craniotomy 10 days later. Histological examination demonstrated a Hyams' grade III neuroblastoma with ectopic expression of vasopressin. He underwent fractionated radiotherapy at a dose of 60 Gy in 30 fractions. Fourteen months after the onset, he is well with no neuroimaging evidence of tumour recurrence. His serum and urine sodium are completely normalised.

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Section: Introductionmentioning

confidence: 95%

Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone

et al. 2010

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“…Differential diagnosis of hyponatremia SIADH should be considered as one of the possible differential diagnoses of hyponatremia [3][4][5]. Previous reports have shown that local and mechanical stressors that compress the pituitary stalk influence the excessive release of ADH.…”

Section: Pathogenesis Of Secondary Adrenal Insufficiencymentioning

confidence: 99%

“…Secondary adrenal insufficiency, one of the major causes of hypo-osmotic hyponatremia, results from hypothalamic or hypophyseal disorders [1]. Causes of pituitary adenoma-induced hyponatremia include hypopituitarism in association with concurrent dysfunction of the pituitary-adrenal axis [2] and the syndrome of inappropriate secretion of ADH (SIADH) [3][4][5]. Among the differential diagnoses of hyponatremia, several reports suggest that a pituitary gland corticotrophic adenoma may lead to impaired processing of mature ACTH.…”

Section: Introductionmentioning

confidence: 99%

Severe hyponatremia caused by secondary adrenal insufficiency in a patient with giant pituitary prolactinoma

et al. 2013

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A 55-year-old-man was admitted to Saiseikai Central Hospital, Tokyo, Japan, complaining of nausea and appetite loss, and was found to have severe hyponatremia. Despite severe hyponatremia and plasma hypo-osmolarity, urinary sodium excretion was not reduced. A brain magnetic resonance imaging (MRI) scan revealed a giant pituitary prolactinoma, and endocrinological tests showed a markedly increased prolactin level. Despite the observation that the basal plasma ACTH level was normal, serum cortisol and urinary cortisol excretion levels were low. Rapid ACTH loading sufficiently stimulated an increase in serum cortisol levels, suggesting secondary adrenal insufficiency. Notably, loading of CRH induced a good ACTH response; however, the serum cortisol response remained low. In contrast, the continuous daily administration of exogenous ACTH dramatically increased serum cortisol levels. These discrepant responses may have been caused by the low biological activity of innate ACTH. Following partial resection of the prolactinoma, postoperative adjuvant therapy with cabergoline effectively reduced prolactin levels, but did not improve the hyponatremia. In contrast, hydrocortisone replacement therapy recovered the serum sodium level to the normal range. The present case is the first report describing a link between severe hyponatremia and biologically inactive circulating ACTH as a likely result of giant prolactinoma.

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“…Valparaíso, Chile . L a hiponatremia (HNA) como forma de presentación de un hipopituitarismo (HPT) ha sido comunicada en diversas situaciones clínicas, pero infrecuentemente como primera manifestación de un tumor hipofisario (TH) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] . El objetivo de esta comunicación fue conocer la frecuencia y características clínicas de esta forma de presentación de los THs.…”

Section: Hyponatremia Associated To Pituitary Adenomas Report Of Thrunclassified

“…Aunque los TH's son una causa común de hipopituitarismo, la HNA sintomática rara vez es su motivo de presentación clínica 6,7 . La HNA se ha observado asociada a adenomas, craneofaringiomas, prolactinomas, quistes, schwanomas, meningiomas, aneurismas, carcinoma nasofaríngeo y metástasis de carcinomas 8,12,[16][17][18][23][24][25][26][27][28] .…”

Section: Casos Clínicosunclassified

Hiponatremia sintomática como forma de presentación clínica de un macroadenoma hipofisiario: Comunicación de tres casos

et al. 2009

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SIADH is only an Atypical Clinical Feature in a Patient with Prolactinoma

Abstract: Abstract

Cited by 10 publications

References 8 publications

Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone

Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone

Severe hyponatremia caused by secondary adrenal insufficiency in a patient with giant pituitary prolactinoma

Hiponatremia sintomática como forma de presentación clínica de un macroadenoma hipofisiario: Comunicación de tres casos

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