SIAH2 regulates colorectal cancer tumorigenesis via PI3K/ATK signaling pathway

Hu, Yongbo; He, Yiming; Liu, Wei; Yu, Sirong; Wei, Yabing; Bai, Shaohua; Su, Yu; Xiao, Bin

doi:10.1016/j.tice.2022.101878

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…Furthermore, it has been observed that DNA methylation pattern within non-CpG island promoter region of DEFB1 can influence epigenetic silencing of DEFB1 in tumor cells [ 39 ]. In colorectal cancer, SIAH2 has been identified as an oncogene [ 40 ]. SIAH2 (Siah E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene.…”

Section: Discussionmentioning

confidence: 99%

Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer

Wang,

Li,

Yang

et al. 2024

Aging

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Background: Breast cancer (BC) is a heterogeneous tumor with a variety of etiology and clinical features. Antibody-dependent cell phagocytosis (ADCP) is the last step of immune checkpoint inhibition (ICI), and macrophages detect and recognize tumor cells, then destroy and engulf tumor cells. Despite the large number, negative regulators that inhibit phagocytic activity are still a key obstacle to the full efficacy of ICI. Patients and methods: An ADCP-related risk score prognostic model for risk stratification as well as prognosis prediction was established in the Cancer Genome Atlas (TCGA) cohort. The predictive value of ADCP risk score in prognosis and immunotherapy was also further validated in the TCGA along with International Cancer Genome Consortium cohorts. To promote the clinical application of the risk score, a nomogram was established, with its effectiveness verified by different methods. Results: In this study, the genes collected from previous studies were defined as ADCP-related genes. In BC patients, two ADCP-related subtypes were identified. The immune characteristics and prognostic stratification were significant different between them. Conclusions: We identified two subtypes associated with ADCP gene expression in breast cancer. They have significant differences in immune cells, molecular functions, HLA family genes, immune scores, stromal scores, and inflammatory gene expression, which have important guiding significance for the selection of clinical treatment methods. At the same time, we constructed a risk model based on ADCP, and the risk score can be used as a good indicator of prognosis, providing potential therapeutic advantages for chemotherapy and immunotherapy, thus helping the clinical decision-making of BC patients.

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Section: Discussionmentioning

confidence: 99%

Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer

Wang,

Li,

Yang

et al. 2024

Aging

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“…Furthermore, it has been observed that DNA methylation pattern within non-CpG island promoter region of DEFB1 can in uence epigenetic silencing of DEFB1 in tumor cells (39) . In colorectal cancer, SIAH2 has been identi ed as an oncogene (40) . It promoted various aggressive behaviors of colorectal cancer cells, such as proliferation, migration, invasion, as well as colony formation (41) .…”

Section: Discussionmentioning

confidence: 99%

Identification of subtype recognition and prognosis model characterized by Antibody-dependent cell phagocytosis related genes in breast cancer

Yang

et al. 2023

Preprint

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Background Breast cancer (BC) is a heterogeneous tumor with a variety of etiology and clinical features. Antibody-dependent cell phagocytosis (ADCP) is the last step of immune checkpoint inhibition (ICI), and macrophages destroy tumor cells after previous recognition activation. Despite the large number, negative regulators that inhibit phagocytic activity are still a key obstacle to the full efficacy of ICI. Patients and methods: An ADCP -related risk score prognostic model for risk stratification as well as prognosis prediction was established in the Cancer Genome Atlas (TCGA) cohort. The predictive value of ADCP risk score in prognosis and immunotherapy was also further validated in the TCGA along with International Cancer Genome Consortium cohorts. To promote the clinical application of the risk score, a nomogram was established, with its effectiveness verified by different methods. Results In this study, the genes collected from previous studies were defined as ADCP-related genes. In BC patients, two ADCP-related subtypes were identified. The immune characteristics and prognostic stratification were significant different between them. Conclusion Based on these findings, it can be inferred that there is a significant relationship between ADCP and TME (tumor microenvironment) in BC. Risk score could be used as a good indicator for prognosis, potential in providing therapeutic advantages for chemotherapy as well as immunotherapy, thereby aiding in the clinical decision-making process for BC patients.

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“…In glioma, SALL4 promotes cell proliferation by inhibiting PTEN expression, thereby activating the PI3K/AKT signaling pathway (Liu et al 2017 ). PTEN, as a tumor suppressor gene, inhibits the PI3K/ AKT pathway in EC, GC, and CRC (Yang et al 2021b ; Liang et al 2021 ; Hu et al 2022 ). SALL4 has been reported to be an upstream regulatory gene of PTEN in gastric cancer (Wang et al 2019a ) and hepatocellular carcinoma (Yong et al 2013 ), but it is unclear whether it has a similar effect on PTEN in esophageal, colorectal, and pancreatic cancer, which needs further investigation.…”

Section: Future Perspectivesmentioning

confidence: 99%

SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms

Wang,

Jin,

Wang

et al. 2024

Mol Med

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Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) cancers. SALL4 is a well-known transcription factor that is involved in organogenesis during embryonic development. Previous studies have revealed that SALL4 regulates cell proliferation, survival, and migration and maintains stem cell function in mature cells. Additionally, SALL4 overexpression is associated with tumorigenesis. Despite its characterization as a biomarker in various cancers, the role of SALL4 in GIT cancers and the underlying mechanisms are unclear. We describe the functions of SALL4 in GIT cancers and discuss its upstream/downstream genes and pathways associated with each cancer. We also consider the possibility of targeting these genes or pathways as potential therapeutic options for GIT cancers.

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SIAH2 regulates colorectal cancer tumorigenesis via PI3K/ATK signaling pathway

Cited by 8 publications

References 20 publications

Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer

Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer

Identification of subtype recognition and prognosis model characterized by Antibody-dependent cell phagocytosis related genes in breast cancer

SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms

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