Sialadenoma papilliferum of the bronchus: Rare tracheobronchial tumor of salivary gland type

Abstract

Presented herein is the second case of sialadenoma papilliferum of the bronchus in a 75-year-old man. The bronchial tumor had an exophytic papillary lesion protruding into the lumen of the ostial region of the right superior lobe bronchus on chest CT and bronchoscopy. Grossly, the resected tumor was pedunculated, 5 x 3 x 3 mm in size and consisted of both an exophytic papillary lesion protruding into the bronchial lumen and a glandular component in the bronchial submucosa. Histologically, the papillary structures were lined by ciliated or non-ciliated columnar epithelium and metaplastic non-keratinizing stratified squamous epithelium. The submucosal glandular components were well circumscribed beneath and in continuity with the papillary lesion. The glandular components of cysts and duct-like structures were lined by a double-layer epithelium composed of luminal cells and basal cells. Sialadenoma papilliferum is a rarely recognized salivary gland tumor, mostly occurring at intraoral mucosal sites including the hard and soft palate and buccal mucosa. There have been sporadic cases of sialadenoma papilliferum of the esophagus, nasopharynx and nasal cavity. To the authors' knowledge only one case of sialadenoma papilliferum of the bronchus has been reported previously.

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

“…It can also occur in the parotid gland, submandibular gland, nasopharynx and esophagus [2,3,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Clinically, there are generally no obvious clinical symptoms with mostly painless growth, but sometime papillary erythema or pedicled lumps, occasional ulcers [3,[32][33][34][35][36][37][38][39][40][41][42][43]. Grossly, most of the lesions presents as a round to oval mass with whitecolored and papillary surface, sharing about 80%.…”

Histopathological evaluation of minor salivary gland papillary–cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm

“…SP was named because of its resemblance to syringocystadenoma papilliferum of the skin, which is an uncommon cutaneous adnexal tumour often harbouring BRAF mutations . SP almost exclusively affects the intraoral minor salivary glands; however, a small number of cases have been reported in major salivary glands, the nasal cavity, or the bronchi . Histologically, SP is characterised by a combination of exophytic projection of the surface squamous epithelium and inward papillary proliferation of duct epithelial cells.…”

Sialadenoma Papilliferum: With Clinicopathologic, Immunohistochemical, Molecular Analysis, and Review of the Literature

“…It can also occur in the parotid gland, submandibular gland, nasopharynx and esophagus 2,4,10,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] . Clinically, there are generally no obvious clinical symptoms with mostly painless growth, but sometime papillary erythema or pedicled lumps, occasional ulcers [31][32][33][34][35][36][37][38][39][40][41] . Grossly, most of the lesions presents as a round to oval mass with white-colored and papillary surface, sharing about 80 percent.…”