Sialic acid and anti-ganglioside antibody levels in children with autism spectrum disorders

Yang, Xiaolei; Liang, Shuang; Wang, Lin; Han, Panpan; Jiang, Xi-Tao; Wang, Jianli; Hao, Yanqiu; Wu, Lijie

doi:10.1016/j.brainres.2017.10.027

Cited by 18 publications

(23 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-GM1 antibodies have been described in motor neuropathies, but also in neurodegenerative diseases such as GM1 gangliosidosis, multifocal motor neuropathy, dementia and Guillain-Barré syndrome (113–116). Two studies have reported increased levels of these antibodies in ASD patients using ELISA, however with widely different sensitivities, varying from 74 to 38%, and corresponding specificities of 95 and 78%, respectively (Table 1) (46, 47). Moreover, in the study by Mostafa et al (46), a significant correlation with disease severity was found, whereas this could not be confirmed in another study (47).…”

Section: Autoantibodies In Asd Patientsmentioning

confidence: 99%

“…Two studies have reported increased levels of these antibodies in ASD patients using ELISA, however with widely different sensitivities, varying from 74 to 38%, and corresponding specificities of 95 and 78%, respectively (Table 1) (46, 47). Moreover, in the study by Mostafa et al (46), a significant correlation with disease severity was found, whereas this could not be confirmed in another study (47). Nevertheless, it seems that anti-GM1 antibodies have been associated with ASD, but their specific role remains to be elucidated.…”

Section: Autoantibodies In Asd Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder

2019

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose behavioral symptoms become apparent in early childhood. The underlying pathophysiological mechanisms are only partially understood and the clinical manifestations are heterogeneous in nature, which poses a major challenge for diagnosis, prognosis and intervention. In the last years, an important role of a dysregulated immune system in ASD has emerged, but the mechanisms connecting this to a disruption of brain development are still largely unknown. Although ASD is not considered as a typical autoimmune disease, self-reactive antibodies or autoantibodies against a wide variety of targets have been found in a subset of ASD patients. In addition, autoantibodies reactive to fetal brain proteins have also been described in the prenatal stage of neurodevelopment, where they can be transferred from the mother to the fetus by transplacental transport. In this review, we give an extensive overview of the antibodies described in ASD according to their target antigens, their different origins, and timing of exposure during neurodevelopment.

show abstract

Section: Autoantibodies In Asd Patientsmentioning

confidence: 99%

Section: Autoantibodies In Asd Patientsmentioning

confidence: 99%

Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder

2019

View full text Add to dashboard Cite

show abstract

“…To our knowledge, there was only one study investigating the relationship between plasma Sia levels and the pathogenesis of ASD in humans. They found that the level of plasma Sia in the control group higher than that in the children with ASD 14). Also, in 2014, a child diagnosed with ASD and epilepsy was found to have a heterozygous 520-kb deletion on chromosome 15q26.1, where ST8SIA2 is located 15).…”

Section: Introductionmentioning

confidence: 99%

Levels of Salivary Sialic Acid in Children with Autism Spectrum Disorder; Could It Be Related to Stereotypes and Hyperactivity?

Demirci

Guler

Özmen

et al. 2019

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

Objective Sialic acid (Sia) is an essential nutrient for brain development, learning, memory and cognition and plays a role in neurodevelopment of infants. The aim of this study was to determine whether Sia levels are significantly associated with the autism spectrum disorder (ASD). Methods Forty-six ASD children and 30 typically developing children aged 3 to 10 years were included in the study. Behavioral symptoms in ASD children was assessed by the Autism Behavior Checklist (AuBC), the Childhood Autism Rating Scale, and the Aberrant Behavior Checklist (ABC). After the collection of saliva samples, the supernatant was separated. All the samples kept at −80°C until Sia analysis was done. Results Sia level was found to be significantly lower in the ASD group when compared to healthy controls ( p = 0.013). There was no correlation between severity of ASD and salivary Sia levels. We found a negative correlation between AuBC scores and Sia levels and a negative correlation in both ABC Stereotypic Behavior and Hyperactivity/Noncompliance subscales with Sia levels in ASD group. Conclusion The obtained data indicate that Sia levels could have an effect on autism-like behaviors, particularly on stereotypes and hyperactivity.

show abstract

“…A more recent GWAS also revealed a relationship between increased expression of a ST3GAL3 transcript in the human fetal brain and a risk for ADHD and schizophrenia ( Hall et al., 2020 ). Moreover, children with ASD often displayed increased anti-ganglioside antibody levels ( Mostafa and Al-Ayadhi, 2011 ; Yang et al., 2018 ) and changes in the ganglioside expression has also been proposed as a biomarker for schizophrenia ( Sarbu et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5

Strekalova

Svirin

Veniaminova

et al. 2021

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Gangliosides are glycosphingolipids, which are abundant in brain, are known to modulate ion channels and cell-to-cell communication. Deficiencies can result in aberrant myelination and altered immune responses, which can give rise to neurodevelopmental psychiatric disorders. However, to date, little mechanistic data is available on how ganglioside deficiencies contribute to the behavioural disorders. In humans, the loss of lactosylceramide-alpha-2,3-sialyltransferase (ST3Gal5) leads to a severe neuropathology, but in ST3Gal5 knock-out ( St3gal5−/− ) mice the absence of GM3 and associated a-, b- and c-series gangliosides is partially compensated by 0-series gangliosides and there is no overt behavioural phenotype. Here, we sought to examine the behavioural and molecular consequences of GM3 loss more closely. Mutants of both sexes exhibited impaired conditioned taste aversion in an inhibitory learning task and anxiety-like behaviours in the open field, moderate motor deficits, abnormal social interactions, excessive grooming and rearing behaviours. Taken together, the aberrant behaviours are suggestive of an autism spectrum disorder (ASD)-like syndrome. Molecular analysis showed decreased gene and protein expression of proteolipid protein-1 ( Plp1 ) and over expression of proinflammatory cytokines, which has been associated with ASD-like syndromes. The inflammatory and behavioural responses to lipopolysaccharide (LPS) were also altered in the St3gal5−/− mice compared to wild-type, which is indicative of the importance of GM3 gangliosides in regulating immune responses. Together, the St3gal5−/− mice display ASD-like behavioural features, altered response to systemic inflammation, signs of hypomyelination and neuroinflammation, which suggests that deficiency in a- and b-series gangliosides could contribute to the development of an ASD-like pathology in humans.

show abstract

Sialic acid and anti-ganglioside antibody levels in children with autism spectrum disorders

Cited by 18 publications

References 29 publications

Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder

Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder

Levels of Salivary Sialic Acid in Children with Autism Spectrum Disorder; Could It Be Related to Stereotypes and Hyperactivity?

ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5

Contact Info

Product

Resources

About