Sialic acid removal modules the myocardial and vascular activity of calcium channel ligands

Sialoglycoconjugates in rat sublingual gland acinar cells, at different stages of pre- and post-natal development, were investigated in situ with specific lectins and by the selective removal of terminal sialic acids. Cleavage of acetyl substituents sited in the pyranose ring and/or polyhydroxyl side chain was used as an additional means of characterising the glycoconjugates. The first expression of terminal sialic acid linked to beta-galactose was found at gestational day 17 and progressive different derivatives were observed. The terminal disaccharide sialic acid-N-acetylgalactosamine was constantly visualized in the sublingual gland from gestational day 18. In both terminal disaccharides, sialic acids were characterized by variable degrees of acetylation and were found to be highly packaged and responsible for the hydration coat. The complex data obtained indicated that the sublingual gland is characterized by a marked fluctuation of complex sialoglycoconjugates that differ from those in the submandibular gland of the same species.

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Sialic acid removal modules the myocardial and vascular activity of calcium channel ligands

Cited by 3 publications

References 28 publications

Biochemistry and Function of Sialidases

Biochemistry and Function of Sialidases

Presence of sialic acid in prothoracic glands of Galleria mellonella (Lepidoptera)

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