2021
DOI: 10.3390/biom11060831
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Sialic Acids as Receptors for Pathogens

Abstract: Carbohydrates have long been known to mediate intracellular interactions, whether within one organism or between different organisms. Sialic acids (Sias) are carbohydrates that usually occupy the terminal positions in longer carbohydrate chains, which makes them common recognition targets mediating these interactions. In this review, we summarize the knowledge about animal disease-causing agents such as viruses, bacteria and protozoa (including the malaria parasite Plasmodium falciparum) in which Sias play a r… Show more

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Cited by 39 publications
(30 citation statements)
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References 207 publications
(226 reference statements)
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“…Deprotected sugars (final products) were lyophilised using a Buchi Lyovapor L-200 freeze dryer. 1 H, COSY, 13 C, DEPT-135 and HSQC NMR spectra were recorded on a Bruker Avance III 400 MHz at 298 K. Chemical shifts (δ) recorded in CDCl3 and D2O are reported with respect to the solvent residual peak at 7.26 and 4.79 ppm in 1 H NMR, respectively. High resolution mass spectra were acquired using electrospray ionisation in a Waters Vion with Waters Acquity LCMS (positive mode).…”
Section: Experimental General Materials and Methodsmentioning
confidence: 99%
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“…Deprotected sugars (final products) were lyophilised using a Buchi Lyovapor L-200 freeze dryer. 1 H, COSY, 13 C, DEPT-135 and HSQC NMR spectra were recorded on a Bruker Avance III 400 MHz at 298 K. Chemical shifts (δ) recorded in CDCl3 and D2O are reported with respect to the solvent residual peak at 7.26 and 4.79 ppm in 1 H NMR, respectively. High resolution mass spectra were acquired using electrospray ionisation in a Waters Vion with Waters Acquity LCMS (positive mode).…”
Section: Experimental General Materials and Methodsmentioning
confidence: 99%
“…The organic layer was dried over MgSO4, filtered, concentrated under vacuum and purified by flash chromatography [cartridge: SNAP Ultra 10g; gradient: 50-100% EtOAc/Hexane (v:v); flow: 12 mL/min] to afford compound 1 as a white solid with 72% yield (370 mg; 0.72 mmol). 1 = 4.8 Hz, H-3eq), 2.14 (3H, s, CH3CO), 2.12 (3H, s, CH3CO), 2.03 (6H, s, 2x CH3CO), 1.88 (3H, s, CH3CONH), 1.87-1.79 (1H, m, H-3ax). 13 C NMR (101 MHz, CDCl3) δ 170.9, 170.7, 170.4, 170.2, 170.1 (4x CH3CO, C-1), 167.2 (CH3CONH), 89.1 (C-2), 74.1 (C-6), 69.6 (C-8), 68.9 (C-4), 67.6 (C-7), 62.2 (C-9), 53.6 (CO2CH3), 49.4 (C-5), 36.7 (C-3), 23.3 (CH3CONH), 21.1, 20.9, 20.8, 20.8 (4x CH3CO).…”
Section: Tcts and Neuraminidase Inhibition Assaysmentioning
confidence: 99%
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