Sialidase Attenuates Epidermal Growth Factor Response and Abolishes Antiproliferative Effects of Erlotinib in A549Alveolar Epithelial Cells

Rybak, Agnieszka; Zarzecki, Mateusz; Golabiewska, E.; Niechoda, A.; Hołownia, Adam

doi:10.1007/5584_2018_329

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Although these studies suggest a controlling function of receptor sialylation, other findings suggest the opposite. Sialidase-treated A549 cells were less sensitive to EGF-stimulated cell proliferation than A549 cells without sialidase treatment, and the TKI erlotinib showed no significant effects upon sialidase treatment [ 51 ]. Britain et al [ 52 ] found that high expression levels of α2,6-sialyltransferase ST6Gal I that acts on complex N -glycans of EGFR correlates with EGF-triggered EGFR activation in pancreatic cancer cells [ 52 , 53 ].…”

Section: Tyrosine Kinase Receptorsmentioning

confidence: 99%

Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death

Gao

Luan

Melamed

et al. 2021

Cells

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Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated. This review discusses receptor glycosylation and the known roles of glycans on the functions of receptors expressed in diverse cell types. We included growth factor receptors that have an intracellular tyrosine kinase domain, growth factor receptors that have a serine/threonine kinase domain, and cell-death-inducing receptors. N- and O-glycans have a wide range of functions including roles in receptor conformation, ligand binding, oligomerization, and activation of signaling cascades. A better understanding of these functions will enable control of cell survival and cell death in diseases such as cancer and in immune responses.

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