Sialoblastoma. diagnosis by <scp>FNAC</scp>: A case report

Kataria, Sant Prakash; Kumar, Sanjay; Singh, Gajender; Kalra, Rajneesh; Sen, Rajeev; Garg, Nitin

doi:10.1002/dc.23324

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…In the screening phase, 103 articles were selected for full‐text evaluation. Of these, 51 selected studies 3,5,7–10,13–57 met the eligibility criteria. Additionally, 1 article 58 was added from a manual search of the reference lists of included studies, resulting in the inclusion of 52 articles in the qualitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

et al. 2023

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Sialoblastoma is a rare malignant salivary gland tumor. The aim of this study was to review the available published data on sialoblastoma in a comprehensive analysis of its clinicopathologic characteristics, treatment, and outcomes. An unrestricted electronic search was performed in the following databases: MEDLINE/PubMed, EMBASE, Scopus, Web of science, and gray literature databases. Eligibility criteria included publications with sufficient clinical, imaging, and histopathological information to confirm the diagnosis of sialoblastoma. Data were evaluated descriptively and analytically. A total of 52 studies met the eligibility criteria. In total, 62 patients were evaluated. There was no gender predilection, with the parotid being the most affected primary site (n = 28; 45.2%). In the log‐rank test, there was a significant increase in disease‐associated survival in patients younger than 1 year of age (82.8% vs. 44.4%; p = 0.003), individuals with lesions in major salivary glands (79.4% vs. 38.5%; p = 0.005), patients without metastases (77.8% vs. 14.3%; p = 0.011), encapsulated lesions (85.7% vs. 0%; p < 0.0001), congenital lesions (83.3% vs. 25.0%; p < 0.0001), and lesions that do not show perineural invasion (89.5% vs. 40%; p = 0.035). Kaplan–Meier curves estimated overall survival and disease‐free survival at 5 years of 95.5% and 68.1%, respectively. In the multivariate Cox regression model, only the presence of metastasis was identified as an independent prognostic factor (hazard ratio [HR] = 9.81; p = 0.010). Although sialoblastoma presents good prognosis, the tumor has a high recurrence rate.

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Section: Resultsmentioning

confidence: 99%

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

et al. 2023

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“…On CT scan, they are detected as lobulated lesions that are isodense to muscle (11,12). On MRI, these tumors show low or intermediate signal intensity on T1-weighted images and intermediate or mildly high signal intensity on T2-weighted images, suggesting a high nucleus-to-cytoplasmic ratio (13)(14)(15). They are usually heterogeneous, with focal areas of necrosis or hemorrhage; these lesions may enhance poorly, heterogeneously, or intensely (7,12,13).…”

Section: Discussionmentioning

confidence: 99%

Sialoblastoma and Hepatoblastoma in an Infant: A Case Report and Review of the Literature

2021

Iran J Radiol

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“…Sialoblastoma is an uncommon tumour of the parotid gland, hypothesised to arise from blastemal components, similar to tumours arising from other visceral organs such as hepatoblastoma and neuroblastoma. There are a handful of reports on the diagnosis of sialoblastoma on FNA cytology . According to Kataria et al, sialoblastoma shows nests, groups and acinar patterns, organoid clusters with a prominent fibromyxoid stroma, similar to that of other matrix‐producing tumours.…”

Section: Discussionmentioning

confidence: 99%

“…There are a handful of reports on the diagnosis of sialoblastoma on FNA cytology . According to Kataria et al, sialoblastoma shows nests, groups and acinar patterns, organoid clusters with a prominent fibromyxoid stroma, similar to that of other matrix‐producing tumours. Because of the prominent nesting pattern, epithelial morphology, ALES is a close mimic of sialoblastoma.…”

Section: Discussionmentioning

confidence: 99%

“…ALES has a relatively higher incidence in the head and neck region of about 5% with unique morphology recapitulating epithelial differentiation with the formation of squamous pearls, peripheral palisading and a diffuse cytokeratin as well as p40 positivity . This tumour encompasses cells with basaloid morphology reminiscent of salivary anlage structures and has an array of morphological patterns with characteristic immunohistochemistry. There are rare reports available on cytomorphological features of ALES .…”

Section: Introductionmentioning

confidence: 99%

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Cytomorphological features of adamantinoma‐like Ewing's sarcoma in parotid masquerading as sialoblastoma in a paediatric patient

et al. 2020

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The incidence of mesenchymal tumours in the salivary gland range from 0.3% to 1%. 1 Adamantinoma-like Ewing sarcoma (ALES) is an unusual variant of Ewing sarcoma with more incidences in the head and neck of young patients, but scarce in the salivary gland. 2 The closest differential is sialoblastoma, also known synonymously as congenital basal cell adenoma/embryoma, another rare tumour of the salivary gland that almost exclusively arises from the parotid gland 3 in infants. ALES exhibits distinct is this meant to be epithelial? morphology and nesting pattern and shows translocation involving EWSR and FLI1, 4,5 like conventional Ewing sarcoma. ALES has a relatively higher incidence in the head and neck region of about 5% with unique morphology recapitulating epithelial differentiation with the formation of squamous pearls, peripheral palisading and a diffuse cytokeratin as well as p40 positivity. 2,4 This tumour encompasses cells with basaloid morphology reminiscent of salivary anlage structures 6 and has an array of morphological patterns with characteristic immunohistochemistry. There are rare reports available on cytomorphological features of ALES. 7 We report an unusual case of ALES of the parotid gland in a 12-year-old, masquerading as sialoblastoma. | C A S E REP ORT | Clinical featuresA 12-year-old girl presented to the clinic with complaints of preauricular swelling for 2 months. Clinical examination revealed a 4 × 3 cm firm, non-tender swelling with well-defined borders, and restricted mobility. Haematological and biochemical investigations were mostly within normal limits. Fine needle aspiration (FNA) was performed with a radiological possibility of pleomorphic adenoma. | MicroscopyAspirate smears were highly cellular with nests and sheets of tumour cells demonstrating peritheliomatous pattern at places. These cells showed epithelioid morphology with moderate atypia, round to ovoid nuclei, finely granular chromatin, and occasional prominent nucleoli. Vague rosetting was also appreciated focally ( Figure 1A-E). As per the Milan System, the morphology fitted in category VI, malignant tumour with epithelioid morphology. Certain unique morphological features, such as a nesting of small round blue cells with epithelioid morphology posed a diagnostic challenge in categorising the lesion. Therefore, on FNA cytology, two possible differentials were suggested; sialoblastoma and Ewing sarcoma/primitive neuroectodermal tumour. Subsequently, superficial parotidectomy with right cervical lymph node excision was done. The specimen was well encapsulated; no macroscopic extracapsular extension was visualised. Cut section revealed a whitish, relatively circumscribed tumour that was replacing the entire salivary gland with patchy areas of congestion reaching up to the capsule ( Figure 1F). Macroscopically, the tumour had replaced the whole of the salivary gland with no visible healthy salivary gland tissue. Microscopic sections, however, displayed rim of normal salivary gland tissue at the periphery, with an ill circumscr...

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Sialoblastoma. diagnosis by FNAC: A case report

Cited by 8 publications

References 10 publications

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

Sialoblastoma and Hepatoblastoma in an Infant: A Case Report and Review of the Literature

Cytomorphological features of adamantinoma‐like Ewing's sarcoma in parotid masquerading as sialoblastoma in a paediatric patient

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