Sialochemistry of patients with autoimmune rheumatic disease with and without histological manifestations of Sjogren's syndrome.

Abstract

SUMMARY Fifty-one patients with autoimmune rheumatic diseases underwent biopsy of the labial minor salivary glands. These patients were divided according to histopathology of lip biopsies into three groups (negative lip biopsy, 1+ and 2+). From all the patients stimulated parotid salivary flow was measured. In the saliva sodium, potassium, magnesium, a-amylase, and immunoglobulin levels (IgA, IgG, IgM) were measured. It is shown that patients with advanced chronic inflammatory disease of the minor salivary glands have decreased stimulated salivary flow. However, no statistically significant differences were observed in the biochemical markers tested between the histopathological groups examined.

Sialochemistry in Sjögren's syndrome: a review

“…Immunoglobulin synthesis did not correlate with the serum concentrations or degree of lymphoid infiltration. A similar finding was arrived at by TsiANOs et al (143), who observed that salivary IgA levels did not correlate with the degree of inflammation of the minor salivary glands in patients with various autoimmune diseases, some of whom had primary SS. An explanation may be that the presence of IgA-producing plasma cells is relatively independent of the intensity of the cellular infiltrate, or that the diseased glandular cells have a reduced capacity for coupling SC to dimeric IgA.…”

Proteomic diagnosis of Sjögren’s syndrome

“…Regarding cystatins expression, a discrepancy was observed between Ryu and colleagues [80], and Giusti and coworkers [81]. Unlike Ryu and colleagues [80] who found an increase in cystatin C, the latter study showed a reduction in cystatin SN precursor and very few or a total absence of other Increased [54] Michalski et al (1975) β2-microglobulin Increased [55] Mandel et al (1976) IgA Increased [56] Tabak et al (1978) Lactoferrin Increased [57] Ghozlan et al (1978) IgG and IgM Differentially expressed [58] Moutsopoulos et al (1980) Lysozyme Increased [59] Pennec et al (1982) β2-microglobulin, IgA, IgG, IgM and lysozyme Increased [60] Stuchell et al (1984) Albumin, IgA, IgG and lactoferrin Increased [61] Tsianos et al (1985) α-amylase, IgG and IgA Decreased [62] Fox et al (1987) Albumin Increased [63] Friberg et al (1988) Kallikrein Unchanged [64] Jezequel et al (1989) Lactoferrin Unchanged [65] Bianucci et al (1992) β2-microglobulin Increased [66] Markusse et al (1992) β2-microglobulin, lysozyme and lactoferrin Increased [67] van der Geest et al (1993) β2-microglobulin Increased [68] Mogi et al (1994) β2-microglobulin Increased [69] Maddali Bongi et al (1995) β2-microglobulin, IgA and IgM Increased [70] van der Reijden (1996) Albumin, cystatin C and S, and IgA Increased [71] Carpenter et al (2000) β2-microglobulin, IgA, lactoferrin Increased [72] Almstäh et al (2001) Albumin Increased …”

Use of Human Minor Salivary Glands in Basic and Applied Secretion Research

“…Certain of these studies attempted to correlate histopathological and sialochemical findings, but these involved sampling of unstimulated whole (Spielman et Presented at the Conference on Evaluation and Management of Salivary Gland Dysfunction, May 15-16, 1986, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 'This investigation was supported in part by grants DE 06373, AM 35975, and DE 07023 from the National Institutes of Health. al., 1982;Ben-Aryeh et al, 1978;Elkon et al, 1983), poststimulation whole (Bhoola et al, 1969), stimulated parotid (Stuchell et al, 1984;Herzberg et al, 1973;Tsianos et al, 1985;Mandel and Baurmash, 1976;Beeley and Chisholm, 1976;Bluestone et al, 1972), or stimulated parotid and sub mandibular saliva (Matthews et al, 1985). There are evidently no reports correlating sialochemical changes in labial minor gland saliva with labial gland histopathological findings in pa tients with Sjogren's syndrome (also, see Mandel, 1980).…”