Sialolipoma: a report of seven cases of a new variant of salivary gland lipoma

Nagao, Toshitaka; Sugano, Isamu; Ishida, Yasuo; Asoh, Akira; Munakata, Shigeru; Yamazaki, Kazuto; Konno, Akiyoshi; Kondō, Yōichirō; Nagao, Kōichi

doi:10.1046/j.1365-2559.2001.01054.x

Cited by 134 publications

(251 citation statements)

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“…Sialolipoma is an uncommon benign tumor of salivary glands characterized by normal adipocytes interlaced with normal salivary gland tissue [1]. To date and in our knowledge 58 cases (including the present cases) have been reported in scientific literature .…”

Section: Introductionmentioning

confidence: 76%

“…The histological characteristics of sialolipoma include the presence of neoplastic mature adipocytes and nonneoplastic salivary gland tissue [1]. Recently periductal fibrosis was suggested as a particular histological image of sialolipomas from MiSG [19].…”

Section: Discussionmentioning

confidence: 99%

“…and is characterized by a non-well circumscribed (absence of a fibrous capsule) proliferation of mature adipocytes [1,15]. The lipoadenoma is characterized by both neoplastic tissues: glandular acini/ductus and adipose [21].…”

Section: Discussionmentioning

confidence: 99%

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Sialolipoma of Minor Salivary Glands: Presentation of Five Cases and Review of the Literature with an Epidemiological Analyze

Huerta

Rivera

Rocha

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Sialolipoma is rare benign neoplasm arise from salivary glands (majors and minors) characterized by neoplastic adipose tissue with scattered non-neoplastic salivary gland acinus. To date 60 cases (including 5 cases reported in the present paper) have been reported in scientific literature. This article presents 5 new cases of sialolipoma affecting minor salivary glands (MiSG) and additionally reviews and analyzes the previously published cases to assess possible demographical differences between sialolipoma from minor and from major salivary glands. Case reports: 5 cases (3 females; 2 males; age means 63.8 years), of sialolipoma from MiSG, are reported. 2 of them were located in buccal mucosa, 1 in upper lip mucosa, 1 in floor of the mouth and 1 in retromolar area. All tumors were composed by neoplastic adipocytes cells interlaced with normal salivary gland acinus cover it by a fibrous tissue capsule. Analyzes of literature showed that MiSG sialolipoma is most frequent in females over 60 years old, therefore and in conclusion this article assess different demographical profile of sialolipoma in respect to their topography.

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Section: Introductionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

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Sialolipoma of Minor Salivary Glands: Presentation of Five Cases and Review of the Literature with an Epidemiological Analyze

Huerta

Rivera

Rocha

et al. 2014

Indian J Otolaryngol Head Neck Surg

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“…Sialolipoma is characteristically composed predominantly of adipose tissue with admixed islands of salivary gland acini, ductal, myoepithelial and basal cells [32]. The epithelial/myoepithelial elements may show focal oncocytic change in some cases [32][33][34][35], but unlike oncocytic lipoadenoma, sialolipoma in general lacks a prominent oncocytic component. The tumor tends to show lobulation with evenly distributed salivary gland elements within the fat.…”

Section: Discussionmentioning

confidence: 99%

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Lau

Thompson

2014

Head and Neck Pathol

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Oncocytic lipoadenoma is an exceedingly uncommon neoplasm of the salivary gland composed of oncocytic epithelium and adipose tissue. Retrospective. Seven cases of oncocytic lipoadenoma were analyzed in order to further characterize the clinical and pathologic features of this rare tumor. The patients included six males and one female who ranged from 40 to 83 years of age (mean 62 years) at presentation. All tumors arose in the parotid gland. Grossly, the tumors were solitary, well circumscribed and had light brown to yellow cut surfaces. Histologically, the tumors were composed of an admixed population of oncocytes and adipocytes in varying proportions, with the lipomatous component ranging from 5 to 70 %. Other common features included the presence of serous acini, ductal elements, sebaceous glands, and a patchy chronic inflammation. Clinical follow up information, available in all cases, with a duration of 3-148 months (mean 57 months), showed no evidence of tumor recurrence. Due to its rarity, oncocytic lipoadenoma can pose problems in diagnosis, although the distinctive morphologic features of this neoplasm allow for separation from more commonly recognized oncocytic neoplasms of the salivary glands.

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“…The term sialolipoma was coined by Nagao et al [12] in 2001 for biphasic salivary gland tumors that contain normal looking salivary gland elements (serous acini and ductal, myoepithelial and basal cells) admixed with a variable but usually prominent fatty tissue component. Although a few foci of oncocytic cells might be encountered in some cases, this variant generally lacks a significant oncocytic component.…”

Section: Sialolipoma (Non-oncocytic Adenolipoma)mentioning

confidence: 99%

Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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Fat-containing tumors of the salivary glands are uncommon. Their wide histological spectrum varies from pure lipomatous neoplasms similar to their cutaneous and soft tissue counterparts to mixed lipoepithelial lesions specific to the salivary glands. With few exceptions, these uncommon lesions affect mainly the elderly, with a mean age at presentation of C50 years and show a predilection for males. A few cases occur in childhood; some of them represent congenital lesions. In decreasing order of frequency, ordinary (soft-tissue type) lipoma, oncocytic lipoadenoma, non-oncocytic sialolipoma, and pleomorphic adenoma/myoepithelioma with extensive lipometaplasia are the main variants of fat containing tumors encountered in the salivary glands. While pleomorphic adenoma/myoepithelioma with lipometaplasia behave in the same way as their non-fat-containing counterparts, other lipomatous salivary gland tumors listed above are cured with simple excision and do not carry a risk of recurrence. Other lipoma variants (spindle cell lipoma, osteolipoma, fibrolipoma, angiolipoma, pleomorphic lipoma, lipoblastoma and hibernoma) are exceptionally rare in the salivary gland. Atypical lipomatous tumors/liposarcoma have been only rarely reported in the salivary gland and they behave in a similar fashion to their soft-tissue counterparts. Diffuse lipomatosis and lobular fatty atrophy are the two tumor-like lesions that might closely mimic sialolipoma, particularly in limited biopsy material without knowledge of the gross findings. This review summarizes the clinicopathological features of the main types of salivary fat-containing lesions and discusses their differential diagnoses.

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Sialolipoma: a report of seven cases of a new variant of salivary gland lipoma

Abstract: We regard sialolipoma as a distinct variant of salivary gland lipoma that can occur in both the major and minor salivary glands. Superficial parotidectomy, or surgical resection in the case of palatal tumours, is an appropriate treatment for this benign tumour.

Cited by 134 publications

References 23 publications

Sialolipoma of Minor Salivary Glands: Presentation of Five Cases and Review of the Literature with an Epidemiological Analyze

Sialolipoma of Minor Salivary Glands: Presentation of Five Cases and Review of the Literature with an Epidemiological Analyze

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Fat-Containing Salivary Gland Tumors: A Review

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