Sialolipoma in Minor Salivary Gland: Case Report and Review of the Literature

Abstract

Sialolipoma is a rare benign neoplasm characterized by a well-circumscribed mass composed of neoplastic mature adipose tissue and non-neoplastic salivary gland elements. A 72-year-old woman presented with a painless swelling located in the hard palate, which had been identified 15 days earlier. Microscopically, the tumor was well-circumscribed consisting of lobular proliferation of the lipomatous tissue with thin fibrous tissue septa containing clustered salivary gland elements. Both the glandular and adipose components were found in almost equal proportion. No atypia in the adipose tissue was observed. The definitive diagnosis was sialolipoma. The patient showed no signs of recurrence 8 months after surgical excision. Including the present case, 35 cases of sialolipoma have been reported in the English literature. Of these 35 cases, 16 cases were located in minor salivary glands. Gender was identified in 14 of these cases with 4 males (28.5%) and 10 females (71.5%). The age distribution was from 27 to 84 years (mean, 61.6 years) and the tumor size ranged from 0.9 to 4 cm (mean, 1.7 cm). The most frequently reported clinical presentation was of a painless swelling (56.3%).

Sialolipoma of Palate: A Rare Histological Diagnosis With Review of Literature

“…61.6 years). 15 5 cases were males & 4 cases were female, thus without any distinct sex predilection (Table 1), which is again in accordance with the fact that no direct sex predilection can be found in the cases affecting minor salivary glands. 14 The lesion size ranged from 1 cm to 3.6 cm (mean 1.8cm) ( Table 1) and on review of available literature it has been found that minor salivary gland sialolipomas tend to be smaller than their major salivary gland counterparts, with average greatest dimension being 1.7 cm.…”

“…Usually the ductal structures exhibit dilatation, hyperplasia and thin fibrous tissue around them. 15 Some authors have reported an intense lymphoid infiltrate, marked ductal dilatation, fibrosis and myxoid change in adipose tissue. 1,5,9 We observed acinar atrophy, ductal dilatation and scarce chronic inflammatory cells but no myxoid areas.…”

“…Moraes et al [15] 72/F Hard palate Painless swelling 15 days 1.7 NED at 8 months 7. Arai Y et al [16] 75/M Palate Painless swelling 3 years 1.2 x 1.2 NED at 21 months 8.…”

Sialolipoma of the Parotid Gland: Case Report

“…[11][12][13][14][15][16][17][18][19] Sialolipom ayırıcı tanısında lipomatosis, adiposit içeriği olan pleomorfik adenom ve adneolipom vardır. 20 Lipomatosis genellikle yaşlılarda görülür ve sialolipomdan fibroz kapsül ile sarılı olmaması ve içeriğinde tükrük bezi hücrelerinin olmaması ile ayrılır. 21 Pleomorfik adenom ise tükrük kanallarının ve koyu boyanan miyoepitelyal hüc-relerin bulunması ile ayrılır.…”

“…21 Pleomorfik adenom ise tükrük kanallarının ve koyu boyanan miyoepitelyal hüc-relerin bulunması ile ayrılır. 10,20 Adenolipom histolojik olarak sialolipom ile benzer görünümdedir fakat asiner hücreleri olmadan adiposit ve duktal yapılar birarada bulunur. 9,10 Sialolipomların tedavisi minör tükrük bezlerinde bezin total eksizyonudur.…”