Sialolipoma of the submandibular gland in a child

Sato, Kaori; Gotoh, Chikashi; Uchida, Hiroo; Kawashima, Hiroshi; Yoshida, Misao; Kitano, Yoshihiro; Kishimoto, Hiroshi

doi:10.1016/j.jpedsurg.2010.09.097

Cited by 22 publications

(19 citation statements)

References 10 publications

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“…In our study, the mean age of the patients was 59 years, with only one case being less than 40 years old. To the best of our knowledge, only 4 cases of oral lipoma in children were reported in English literatures [17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Lipomas of the Oral Cavity: Clinicopathological and Immunohistochemical Study of 24 Cases and Review of the Literature

Naruse

Yanamoto

Yamada

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Although lipomas are common soft tissue tumors, few cases of lipoma or its variants have been reported in the oral cavity. We here described the clinical, histological, and immunohistochemical features of 24 cases of oral lipoma obtained from medical records at Nagasaki University Hospital between 1977 and 2010, and also retrospectively reviewed 603 cases of oral lipoma reported in the English literatures. The patients examined comprised 11 men and 13 women with a mean age of 59 years, ranging from 31 to 90 years. The main sites involved were the buccal mucosa (n = 9), followed by the tongue (n = 4), lip and retromolar area (n = 3), floor of the mouth (n = 2), and gingiva (n = 1). The mean tumor size was 2.0 cm, ranging from 0.2 to 5 cm. Histological analysis revealed 20 cases of lipoma, 2 cases of fibrolipoma, and one case each of intramuscular lipoma and spindle cell lipoma. Twenty-three cases were treated surgically while one case underwent biopsy and follow-up. Recurrence was not observed in any case. We reviewed the English literatures, and similar results were obtained. In immunohistochemical analysis, PCNA and ki-67 expression indices were higher in intramuscular lipoma cases than in its variants. Especially, it showed that a long time follow-up may be necessary in ki-67 positive cases.

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Section: Discussionmentioning

confidence: 99%

Lipomas of the Oral Cavity: Clinicopathological and Immunohistochemical Study of 24 Cases and Review of the Literature

Naruse

Yanamoto

Yamada

et al. 2014

Indian J Otolaryngol Head Neck Surg

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“…Although a few foci of oncocytic cells might be encountered in some cases, this variant generally lacks a significant oncocytic component. Close resemblance of sialolipoma to normal salivary gland architecture and its occasional occurrence in childhood allowed some authors to suggest a hamartomatous origin [13][14][15][16][17][18]. The term sialolipoma was included in the most recent 2005 world health organization (WHO) Classification of Head and Neck Tumors [2].…”

Section: Sialolipoma (Non-oncocytic Adenolipoma)mentioning

confidence: 99%

Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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Fat-containing tumors of the salivary glands are uncommon. Their wide histological spectrum varies from pure lipomatous neoplasms similar to their cutaneous and soft tissue counterparts to mixed lipoepithelial lesions specific to the salivary glands. With few exceptions, these uncommon lesions affect mainly the elderly, with a mean age at presentation of C50 years and show a predilection for males. A few cases occur in childhood; some of them represent congenital lesions. In decreasing order of frequency, ordinary (soft-tissue type) lipoma, oncocytic lipoadenoma, non-oncocytic sialolipoma, and pleomorphic adenoma/myoepithelioma with extensive lipometaplasia are the main variants of fat containing tumors encountered in the salivary glands. While pleomorphic adenoma/myoepithelioma with lipometaplasia behave in the same way as their non-fat-containing counterparts, other lipomatous salivary gland tumors listed above are cured with simple excision and do not carry a risk of recurrence. Other lipoma variants (spindle cell lipoma, osteolipoma, fibrolipoma, angiolipoma, pleomorphic lipoma, lipoblastoma and hibernoma) are exceptionally rare in the salivary gland. Atypical lipomatous tumors/liposarcoma have been only rarely reported in the salivary gland and they behave in a similar fashion to their soft-tissue counterparts. Diffuse lipomatosis and lobular fatty atrophy are the two tumor-like lesions that might closely mimic sialolipoma, particularly in limited biopsy material without knowledge of the gross findings. This review summarizes the clinicopathological features of the main types of salivary fat-containing lesions and discusses their differential diagnoses.

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“…[1] Combined mesenchymal tumors like sialolipoma, lipoadenomas, angiolipomas have been described only exceptionally in salivary glands with most of the cases being reported in parotid gland. [1–4] Only four cases of sialolipomas have been described till now in the submandibular gland with three occurring in adults and one in a child. [4] However, to the best of our knowledge, no case of submandibular gland hamartoma comprising such myriad structures including salivary gland ducts, skeletal muscle fibers and nerve within a vessel wall has been described in literature.…”

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confidence: 99%