2019
DOI: 10.1080/1028415x.2019.1691856
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Sialylated milk oligosaccharides alter neurotransmitters and brain metabolites in piglets: an In vivo magnetic resonance spectroscopic (MRS) study

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Cited by 21 publications
(18 citation statements)
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“…The neural cell membranes contain 20 times more SA than other types of membranes, suggesting that SA plays an important role in neural structure ( 160 , 161 ). Therefore, whether SL has an effective role in promoting neurodevelopment by altering the concentration of important brain metabolites and neurotransmitters attracted many research attentions.…”
Section: Effects Of Sialylated Milk Components On Neonatal Gut Microbiota and Healthmentioning
confidence: 99%
See 1 more Smart Citation
“…The neural cell membranes contain 20 times more SA than other types of membranes, suggesting that SA plays an important role in neural structure ( 160 , 161 ). Therefore, whether SL has an effective role in promoting neurodevelopment by altering the concentration of important brain metabolites and neurotransmitters attracted many research attentions.…”
Section: Effects Of Sialylated Milk Components On Neonatal Gut Microbiota and Healthmentioning
confidence: 99%
“…And they can also enhance T-maze performance, increased expression level of mRNA glial fibrillary acidic protein gene encoding, and as well as the expression level of myelin basic protein and myelin-associated glycoprotein in piglets ( 121 ). In the year of 2019 ( 161 ), Wang et al found a significant increasing effects of SL supplementation on the absolute levels of myo-inositol (mIns) and glutamate + glutamine (Glx) in piglets. They also detected significant positive correlations of brain N-acetylaspartate (NAA), total NAA, mIns, total choline, total creatine, scyllo-Inositol (SI) and glutathione with total white matter volume; Glu and SI with whole brain volume; and SI with whole brain weight respectively.…”
Section: Effects Of Sialylated Milk Components On Neonatal Gut Microbiota and Healthmentioning
confidence: 99%
“…Additional animal work revealed changes in white matter composition and connectivity in pigs fed 3 -SL [210]. A recent study found that a combination of 3 -SL and 6 -SL altered multiple brain metabolites and neurotransmitters in suckling piglets compared to control-fed littermates [211]. Together, these reports associating sialylated HMOs with changes in brain structure and signaling suggest that sialylated HMOs promote cognitive function in the developing brain.…”
Section: Cognitive Developmentmentioning
confidence: 90%
“…It also has an important role in anticariogenesis; CGMP inhibits adherence of oral bacteria, preventing tooth decay [44,45]. In animal experiments, a CGMP enriched infant formula increased learning ability, which was linked to an increase in sialioprotein in the frontal brain cortex [46]. These findings need further investigation.…”
Section: Potential Clinical Properties Of Cgmpmentioning
confidence: 96%