Sialylation status in placentas from pregnancies with SARS-CoV-2 infection

Perna, Angelica; Tani, Akio; Sellitto, Carmine; Marini, Mirca; Verde, Marco La; Luca, Antonio De; Guerra, Germano; Lucariello, Angela; Manetti, Mirko; Sgambati, Eleonora

doi:10.1016/j.tice.2023.102074

Cited by 2 publications

(1 citation statement)

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“…In other studies, data have been revealed indicating a change in the presence of sialic acid, related to the morphofunctionality of placental cells [ 173 , 174 ], that leads to different complications such as intrauterine growth retardation, hypertensive disorders, altered glycemia, and gestational trophoblastic tumor. This is the reason for the low presence of α2,3 Galactose-linked Sias in the trophoblast observed in infected placentas, which could be associated with histopathological damage to the placenta [ 175 ].…”

Section: Viral Mechanisms Could Cause Potential Damage To the Placentamentioning

confidence: 99%

Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome

Cruz-Holguín,

González-García,

Velázquez-Cervantes

et al. 2024

Diseases

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In mammals, the placenta is a connection between a mother and a new developing organism. This tissue has a protective function against some microorganisms, transports nutrients, and exchanges gases and excretory substances between the mother and the fetus. Placental tissue is mainly composed of chorionic villi functional units called trophoblasts (cytotrophoblasts, the syncytiotrophoblast, and extravillous trophoblasts). However, some viruses have developed mechanisms that help them invade the placenta, causing various conditions such as necrosis, poor perfusion, and membrane rupture which, in turn, can impact the development of the fetus and put the mother’s health at risk. In this study, we collected the most relevant information about viral infection during pregnancy which can affect both the mother and the fetus, leading to an increase in the probability of vertical transmission. Knowing these mechanisms could be relevant for new research in the maternal–fetal context and may provide options for new therapeutic targets and biomarkers in fetal prognosis.

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Section: Viral Mechanisms Could Cause Potential Damage To the Placentamentioning

confidence: 99%