Sibling and self ovum donation for sisters with an intermediate FMR1 mutation: what's a program to do?

Rybak, Eli A.; Bevilacqua, Kris; Veit, Christina R.; Klugman, Susan; Santoro, Nanette

doi:10.1016/j.fertnstert.2009.03.101

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Possible limitations of this procedure are mentioned, including problems with family relations (Gidoni et al 2008 ). The second report describes a sister-to-sister oocyte donation, where both sisters have intermediate-size mutations in fragile X mental retardation, with an increased risk for POI (Rybak et al 2009 ). This report revealed that both sisters preferred sibling donation over anonymous oocyte donation, despite possible problems in family relations.…”

Section: Discussionmentioning

confidence: 99%

Intrafamilial oocyte donation in classic galactosemia: ethical and societal aspects

Haskovic

Poot

Golde

et al. 2018

J of Inher Metab Disea

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Classic galactosemia is a rare inherited disorder of galactose metabolism. Primary ovarian insufficiency (POI) with subfertility affects > 80% of female patients and is an important concern for patients and their parents. Healthcare providers are often consulted for subfertility treatment possibilities. An option brought up by the families is intrafamilial oocyte donation (mother-to-daughter or sister-to-sister). In addition to POI, galactosemia patients can also present varying cognitive and neurological impairments, which may not be fully clear at the time when mother-to-daughter oocyte donation is considered. Ethical and societal aspects arise when exploring this option. This study aimed to provide guidance in aspects to consider based on the views of different groups involved in the oocyte donation process. A qualitative study using in-depth semi-structured interviews with > 50 participants (patients, family members, and healthcare providers) was conducted. From these interviews, themes of concern emerged, which are illustrated and reviewed: (1) family relations, (2) medical impact, (3) patients’ cognitive level, (4) agreements to be made in advance and organization of counseling, (5) disclosure to the child, and (6) need for follow-up. We conclude that discussing and carrying out intrafamilial oocyte donation in galactosemia patients requires carefully addressing these themes. This study adds value to the already existing recommendations on intrafamilial oocyte donation in general, since it highlights important additional aspects from the perspectives of patients and their families.Electronic supplementary materialThe online version of this article (10.1007/s10545-018-0179-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Intrafamilial oocyte donation in classic galactosemia: ethical and societal aspects

Haskovic

Poot

Golde

et al. 2018

J of Inher Metab Disea

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“…While environmental differences are hypothesized to underlie the observed associations between clinic location and donor egg IVF success, a number of unquantified variables could very well explain the observed directionality of association. Regional practice differences in IVF protocols, such as choice of ovarian suppression strategy, gonadotropin type and dose, and peak estradiol levels prior to ET [49], donor characteristics such as age and sibling donor [50], as well as regional differences in donor egg recipient profiles such as obesity [51], uterine factor [52,53], presence of hydrosalpinges [54] and even vitamin D deficiency [55] could underlie the observed phenomenon. The publically accessible data reported by SART include cumulative annual data for the reporting clinics; details on individual egg donors and recipients are lacking; similarly, in the absence of information on timing of the undertaken ART cycle/s, any inference regarding site specific UVB values during the time of ART cycle, or effect of seasonality cannot be attained.…”

Section: Discussionmentioning

confidence: 99%

Donor egg IVF model to assess ecological implications for ART success

Pal

Kidwai

Kayani

et al. 2014

J Assist Reprod Genet

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Purpose Environmental influences on reproductive success are recognized. We hypothesized that location of fertility clinics may influence treatment success and explored this hypothesis utilizing donor egg IVF (IVF) embryo transfer (ET) model. Methods Publicly accessible national registry data (Society for Assisted Reproductive Technology) on fresh & frozen (FET) ET cycles undertaken at participating clinics across North America (n=444 IVF centers) for 2007 were utilized. Information on number of donor egg IVF cycles, live birth (LB) rate following fresh and frozen ET(FET), average number (#) of ET and IVF center's location, geographical coordinates (latitude, longitude, altitude), annualized average temperatures and midyear regional ultraviolet B (UVB) radiation intensity were obtained. Multivariable logistic regression analyses assessed relationship between LBR (in tertile and uppermost versus lesser quartiles) following fresh and FET with geographical coordinates (region and altitude of clinic location) and ecological influences (average temperature and midyear UVB intensity), adjusting for #ET and clinic experience with donor egg IVF. Results Average number of fresh ET, clinic location (region) and midyear UVB intensity were positive predictors of LBR following fresh ET, whereas altitude and annualized average regional temperature demonstrated an inverse relationship with LBR following fresh ET. For FET cycles, #ET, clinic region and altitude were positive determinants of increasing LBR's. Annualized regional temperature and midyear UVB failed to demonstrate any relationship with LB following donor egg FET. Conclusion Our data suggest that ecological influences may relate to donor egg IVF cycle success. Future studies are needed to better elucidate the mechanisms that could explain the observed associations.

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“…Although most POF cases probably result from de novo mutations [ 10 ], the genetics of this disorder are complex and have not yet been fully elucidated. Accordingly, any POF patient who contemplates sister oocyte donation should be advised about the possibility that any oocytes donated by a sister might carry a POF mutation [ 11 , 12 ]. Anonymous donor oocyte IVF is generally regarded as having a better reproductive outcome than IVF involving a related oocyte donor [ 13 ], and special ethical considerations exist with sibling gamete donation that do not apply in anonymous oocyte donation.…”

Section: Discussionmentioning

confidence: 99%

IVF for premature ovarian failure: first reported births using oocytes donated from a twin sister

Sills

Brady

Omar³

et al. 2010

Reprod Biol Endocrinol

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BackgroundPremature ovarian failure (POF) remains a clinically challenging entity because in vitro fertilisation (IVF) with donor oocytes is currently the only treatment known to be effective.MethodsA 33 year-old nulligravid patient with a normal karyotype was diagnosed with POF; she had a history of failed fertility treatments and had an elevated serum FSH (42 mIU/ml). Oocytes donated by her dizygotic twin sister were used for IVF. The donor had already completed a successful pregnancy herself and subsequently produced a total of 10 oocytes after a combined FSH/LH superovulation regime. These eggs were fertilised with sperm from the recipient's husband via intracytoplasmic injection and two fresh embryos were transferred to the recipient on day three.ResultsA healthy twin pregnancy resulted from IVF; two boys were delivered by caesarean section at 39 weeks' gestation. Additionally, four embryos were cryopreserved for the recipient's future use. The sister-donor achieved another natural pregnancy six months after oocyte retrieval, resulting in a healthy singleton delivery.ConclusionPOF is believed to affect approximately 1% of reproductive age females, and POF patients with a sister who can be an oocyte donor for IVF are rare. Most such IVF patients will conceive from treatment using oocytes from an anonymous oocyte donor. This is the first report of births following sister-donor oocyte IVF in Ireland. Indeed, while sister-donor IVF has been successfully undertaken by IVF units elsewhere, this is the only known case where oocyte donation involved twin sisters. As with all types of donor gamete therapy, pre-treatment counselling is important in the circumstance of sister oocyte donation.

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Sibling and self ovum donation for sisters with an intermediate FMR1 mutation: what's a program to do?

Cited by 7 publications

References 16 publications

Intrafamilial oocyte donation in classic galactosemia: ethical and societal aspects

Intrafamilial oocyte donation in classic galactosemia: ethical and societal aspects

Donor egg IVF model to assess ecological implications for ART success

IVF for premature ovarian failure: first reported births using oocytes donated from a twin sister

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