Sibutramine (Reductil®)-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report

Abstract

A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil®, Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months later the skin lesions recurred on other sites on the lower extremities when the patient was rechallenged with the same drug for 2 weeks. Herein, we report the first case of necrotizing vasculitis induced by sibutramine.

Persistent Organic Chemicals in the Pacific Basin Countries: An Overview

“…Also some perfluorinated compounds were also restricted in 2015 with permanent exemption until development of alternatives (until 2025) (30). Reductil, a pharmaceutical chemical was banned in 2010 due to side effects such as stroke and myocardial infarction (32). Polyhexamethylene guanidine, oligo (2-(2-ethoxy) ethoxyethyl guanidine chloride)-humidifier germicides were banned in 2011 (33).…”

Efficacy of Alismatis Orientale Rhizoma on Obesity induced by High Fat Diet

“…24) , 이 중에서도 약물치료법이 대 중적으로 이용되고 있으나, 약물의 부작용으로 인해 문제가 되고 있다 8) . 예를 들면, 식욕억제제로 비만 치료에 사용되는 약물인 Reductil(성분명 Sibutramine)은 심혈관계에 부작용 을 유발하여 우리나라에서 판매가 중단되었고 25,26) , 지방 소화 억제제인 Xenical(성분명 Orlistat)는 여러 가지 부작용을 일 으키고 있는 것으로 밝혀지고 있기 때문에 27,28) , 최근 천연물 을 소재로 한 항비만물질에 대한 연구가 활발해지고 있다 8,10) . 한의학에서는 비만의 원인을 주로 痰, 濕, 氣滯, 瘀血 등의 원인으로 발생한다고 판단하며, 치료 방법으로는 약물요법, 식욕억제, 행동요법 등을 시행하고 있으며, 이 중에서 약물요 법의 치료법으로는 氣血을 운행시키고, 痰을 없애며, 活血祛 瘀하는 등의 치료법을 실시하고 있다 5) .…”

Drug-induced leukocytoclastic vasculitis: tigecycline a rare cause

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