Sicca Syndrome in Hospitalized Older Adults: Prevalence and Comparison of Objective and Subjective Symptoms

Deschasse, Guillaume; Steenpass, V.; Couturier, Pascal; Diot, Élisabeth; Maillot, F.; Maruani, Annabel

doi:10.1111/j.1532-5415.2011.03639.x

Cited by 4 publications

(5 citation statements)

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“…Symptoms of mouth dryness include a sensation of thirst, soreness and dryness of the lips and oral mucosa [7,8]. It is associated with an increased risk of caries, oral candidiasis, removable denture intolerance, taste disturbance and pneumonia, with a subsequent risk of eating difficulties, choking, loss of appetite and malnutrition [6,[8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…In the elderly, the main cause of xerostomia is medication and, in particular, the use of ‡4-5 drugs per day [2]. More than 500 medications are associated with xerostomia, with special emphasis placed on psychotropic drugs (anticholinergic drugs/atropinics, neuroleptics, tricyclic antidepressants, antipsychotics, benzodiazepines), followed by anti-hypertensives, diuretics, anti-neoplastics, opiates, bronchodilatators, proton pump inhibitors, antihistamines and others [6][7][8][9]16,17]. However, few medications except for true anticholinergic drugs have been demonstrated to affect salivary function and polypharmacy remains the most prevalent cause of mouth dryness [4,14,16].…”

Section: Introductionmentioning

confidence: 99%

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Antiseptic mouthwashes could worsen xerostomia in patients taking polypharmacy

Chevalier¹,

Sakarovitch²,

Prêcheur³

et al. 2015

Acta Odontologica Scandinavica

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiseptic mouthwashes could worsen xerostomia in patients taking polypharmacy

Chevalier¹,

Sakarovitch²,

Prêcheur³

et al. 2015

Acta Odontologica Scandinavica

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“…In contrast, 52.9% of patients who did not report improved xerostomia had increased salivary flow rates. The inconsistency between the xerostomia and the objective index of the salivary flow rate has been previously reported [ 42 ]. Due to these inconsistent findings, it is unclear how much the salivary flow rate must increase to improve xerostomia.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of medication-induced xerostomia and effect of treatment

et al. 2023

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Objective Side-effects of medications cause xerostomia. There have been cases where a medication has been discontinued owing to its severe side-effects. Therefore, the xerostomia must be treated to ensure that the primary disease is managed effectively. This study analyzed the actual status of patients with medication-induced xerostomia and investigates factors associated with its improvement. Methods This study assessed 490 patients diagnosed with medication-induced xerostomia who had an unstimulated salivary flow of ≤0.1 mL/min and received treatment for xerostomia at a xerostomia clinic. Patient age, sex, medical history, medications used, disease duration of xerostomia, and psychological disorders were recorded. The anticholinergic burden was assessed using the Anticholinergic Cognitive Burden scale. The unstimulated salivary flow was measured by the spitting method. According to their symptoms and diagnoses, the patients were introduced to oral lubricants, instructed on how to perform massage, and prescribed Japanese herbal medicines, and sialogogues. Factors associated with the subjective improvement of xerostomia and objective changes in the salivary flow rate were recorded at six months. Results Xerostomia improved in 338 patients (75.3%). The improvement rate was significantly lower in patients with psychiatric disorders (63.6%) (P = 0.009). The improvement rate decreased as more anticholinergics were used (P = 0.018). However, xerostomia improved in approximately 60% of patients receiving three or more anticholinergics. The unstimulated salivary flow increased significantly more in patients who reported an improvement of xerostomia (0.033±0.053 mL/min) than in those who reported no improvement (0.013±0.02 mL/min) (P = 0.025). Conclusion Xerostomia treatment improved oral dryness in 75.3% of patients receiving xerogenic medications in this study. If xerostomia due to side-effects of medications can be improved by treatment, it will greatly contribute to the quality of life of patients with xerogenic medications and may reduce the number of patients who discontinue medications.

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“…This finding is in agreement with an earlier study that reported no statistically significant association between subjective complaints of xerostomia and the objective measurement of unstimulated saliva volume. 4 One possible explanation for this discrepancy is that tolerance for xerostomia, like tolerance for pain, varies greatly between individuals. 17 In the present study, we focused on the presence of xerostomia because it greatly affects QOL.…”

Section: Discussionmentioning

confidence: 99%

“…3 The agreement between xerostomia and the objective measurement of unstimulated salivary flow was only 47.1%. 4 Cause of hyposalivation include various systemic diseases, including Sjögren's syndrome, anticholinergic effects of medications, psychological conditions, irradiation, and physiological changes. 5,6 Because secretion of saliva is controlled by the autonomic nervous system, it is possible that decreases in circulating female hormone induce hyposalivation.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with xerostomia in perimenopausal women

Shinohara

Ito

Takamatsu

et al. 2021

J of Obstet and Gynaecol

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Objectives: Various oral symptoms, including xerostomia and burning mouth syndrome, may occur in menopausal women. These symptoms reduce quality of life (QOL). However, the actual condition of xerostomia after menopause is not clear. The purpose of this study was to reveal the factors associated with xerostomia in perimenopausal women. Methods: Participants included 118 outpatients (mean age, 49.9 AE 3.2 years; range, 45-55 years) at a department of gynecology in Japan. Information was collected concerning age, medical history, medications, menstrual status, and history of treatment for climacteric symptoms. Oral symptoms, including xerostomia were evaluated with a 3-point scale. The climacteric symptom checklist for Japanese women and 36-Item Short-Form Health were used to evaluate climacteric symptoms and QOL, respectively. In addition, the volume of unstimulated saliva, oral moisture, salivary α-amylase, chromogranin A, and 17-β estradiol were measured. Results: Higher age, the total number of medications, psychotropic drug, hormone replacement therapy, treatment for climacteric symptoms, sticky mouth, burning sensation of tongue, dryness of nose and 14 of the 21 climacteric symptoms significantly affected xerostomia. In addition, treatment for climacteric symptoms, fall asleep but often awake at night, headaches and dryness of nose were significantly associated with xerostomia. In conclusion, xerostomia is closely associated to factors such as treatment for climacteric symptoms and certain menopausal symptoms, and it may be related to QOL in perimenopausal women.

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Sicca Syndrome in Hospitalized Older Adults: Prevalence and Comparison of Objective and Subjective Symptoms

Cited by 4 publications

References 6 publications

Antiseptic mouthwashes could worsen xerostomia in patients taking polypharmacy

Antiseptic mouthwashes could worsen xerostomia in patients taking polypharmacy

Characteristics of medication-induced xerostomia and effect of treatment

Factors associated with xerostomia in perimenopausal women

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