People’s well-being, health and productivity in indoor environments are crucial areas of investigation, particularly concerning sick building syndrome (SBS). Sick building syndrome encompasses symptoms resulting from exposure to harmful factors associated with building use. Headaches, fatigue, malaise and nausea are amongst the complaints associated with SBS. A literature review was conducted, examining studies from Scopus and Web of Science to identify the major impacts of SBS on health, well-being and productivity. Out of 3601 initially identified articles, 134 were analyzed after applying predefined criteria. Three research questions (RQs) were formulated, leading to the following findings: (i) most studies focused on offices (35.48%), highlighting common respiratory symptoms that range from mild to severe based on individual sensitivity, indoor conditions and predictive factors; (ii) indoor air quality (IAQ) emerged as the primary factor influencing SBS, especially within the post-pandemic context. Increasing air circulation and ventilation are viable alternatives to enhance IAQ. (iii) Understanding SBS proves complex, with indications of potentially higher symptom frequencies in women due to historical factors, social roles, lower cold tolerance, limited understanding of female physiology and multiple chemical sensitivity.