Sick leave and medication use in pregnancy: a European web-based study

Truong, Bich; Lupattelli, Angela; Kristensen, Petter; Nordeng, Hedvig

doi:10.1136/bmjopen-2016-014934

Cited by 21 publications

(28 citation statements)

References 32 publications

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“…In this study, young-reproductive women exhibited the longest duration of SA due to musculoskeletal diagnoses of the three age groups. However, no conclusions about pregnancy and the increased IRR for low back pain in younger women can be made from this study, as it could be attributable to other factors such as child care and other unpaid domestic work demands [22,24].…”

Section: Plos Onementioning

confidence: 84%

“…Interestingly, there are other diagnostic groups in which the incidence trend significantly decreases from the highest rates in early-reproductive to lowest in late-reproductive women. Some of those diagnosis groups contain pathologies, which could be linked not only to factors related to age itself, but to the different birthrates along the life course, such as musculoskeletal, genitourinary, and other poorly-defined diseases [ 24 ]. Low back pain, nausea and vomiting, and pelvic girdle pain are some of the most common diseases during pregnancy, and contribute to much of the SA throughout this physiological state [ 24 – 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some of those diagnosis groups contain pathologies, which could be linked not only to factors related to age itself, but to the different birthrates along the life course, such as musculoskeletal, genitourinary, and other poorly-defined diseases [ 24 ]. Low back pain, nausea and vomiting, and pelvic girdle pain are some of the most common diseases during pregnancy, and contribute to much of the SA throughout this physiological state [ 24 – 27 ]. The significantly higher IR and IRR observed for early-reproductive and, to a lesser extent (IRR not significantly higher), middle-reproductive groups compared to the late-reproductive women in this cohort, suggests that reproductive age is an important predictor for SA episodes due to these symptoms, which are known to be frequent in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…genitourinary, and other poorly-defined diseases [24]. Low back pain, nausea and vomiting, and pelvic girdle pain are some of the most common diseases during pregnancy, and contribute to much of the SA throughout this physiological state [24][25][26][27].…”

Section: Plos Onementioning

confidence: 99%

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Do birthrates contribute to sickness absence differences in women? A cohort study in Catalonia, Spain, 2012-2014

et al. 2020

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This study explores the differences in sickness absence trends in women according to reproductive age group and medical diagnoses. Methods Data were obtained from two administrative registries: the Continuous Working Life Sample and the Catalonian Institute of Medical Evaluations from 2012 to 2014, containing 47,879 female employees. Incidence rates and incidence risk ratios derived from Poisson and negative binomial models were calculated to compare sickness absence trends among reproductive age groups based on Catalonian birthrates: early-reproductive (25-34 years old), middle-reproductive (35-44) and late-reproductive (45-54), according to diagnostic groups, selected diseases, type of contract, occupational category, and country of origin. Results Younger women show a higher incidence of overall sickness absence compared to latereproductive-aged women. Incidence risk ratios of sickness absence decreased significantly from early-reproductive to late-reproductive age for low back pain, hemorrhage in early pregnancy, nausea and vomiting, and abdominal and pelvic pain. Discussion The higher incidence of sickness absence due to pregnancy-related health conditions in early-reproductive women compared to other reproductive age groups, may explain the sickness absence differences by age in women. Proper management of sickness absence related to pregnancy should be a goal to reduce the sickness absence gap between younger and older women.

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Section: Plos Onementioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

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Do birthrates contribute to sickness absence differences in women? A cohort study in Catalonia, Spain, 2012-2014

et al. 2020

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“…The primary reason for that seems to be pregnancy-related but a mismatch between pregnancy and work, for instance work-family conflicts, workload and reproductive occupational hazards,4–7 and different polices for sick leave during pregnancy across countries also play a role 3. Women not covered by paid sick leave during pregnancy might have higher threshold for calling in sick due to economic challenges.…”

Section: Introductionmentioning

confidence: 99%

Night work and sick leave during pregnancy: a national register-based within-worker cohort study

et al. 2019

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ObjectiveThe aim of our study was to investigate the acute effect of night work during pregnancy on the risk of calling in sick the following day using register-based information and the workers as their own controls.MethodsUsing the payroll-based national Danish Working Hour Database, including all public hospital employees in Denmark, we identified 9799 pregnant women with ≥1 day shift and ≥1 night shift and ≥1 day of sick leave during the first 32 pregnancy weeks from January 2007 to December 2013. We performed fixed effects logistic regression, that is, within-worker comparisons, of the risk of sick leave of any duration starting within 24 hours after night shifts of different length versus day shifts.ResultsMost of the participants were nurses (64%) or physicians (16%). We found an increased relative risk of sick leave following night shifts compared with day shifts during all pregnancy trimesters. The risk was highest for night shifts lasting >12 hours (OR 1.37, 95% CI 1.15 to 1.63 for nurses; OR 1.87, 95% CI 1.69 to 2.08 for physicians) and among women aged >35 years (OR 1.42, 95% CI 1.24 to 1.63).ConclusionAmong Danish public hospital employees night shifts during pregnancy, especially shifts longer than 12 hours, increased the risk of calling in sick the following day independent of personal factors and time-invariant confounders in all pregnancy trimesters.

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Postpartum Psychiatric Outcomes and Sick Leave After Discontinuing SSRI or SNRI in Pregnancy

Cesta,

Reutfors,

Cohen

et al. 2024

JAMA Netw Open

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ImportanceSelective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are consistently reported to be discontinued by approximately half of pregnant women. Little is known about how this may be associated with postpartum psychiatric health.ObjectiveTo investigate associations of SSRI or SNRI discontinuation in pregnant women with depression or anxiety and psychiatric health and sick leave absence after childbirth.Design, Setting, and ParticipantsThis population-based cohort study was conducted between 2006 and 2019 using data from Swedish population-based registers. Pregnant women with a filled prescription of an SSRI or SNRI in the 90 days before pregnancy without recorded comorbid or severe psychiatric conditions were included. Analyses were performed in November 2023.ExposuresK-means for longitudinal data was used to cluster trajectories of SSRI and SNRI use during pregnancy, resulting in 2 trajectory groups based on the number of days covered, defined as continued and discontinued use groups.Main Outcomes and MeasuresThe primary outcome was psychiatric-related hospitalizations by 90 days after childbirth. Secondary outcomes included psychiatric-related outpatient visits, self-harm and suicide, and any-cause mortality by 90 days after childbirth and all outcomes plus sick leave absence by 1.5 years after childbirth.ResultsAmong 27 773 pregnant women (17 241 aged ≥30 years [62.1%] at childbirth), 13 184 women (47.5%) had discontinued SSRI or SNRI use and 14 589 individuals (52.5%) had continued use. Individuals in the discontinued compared with continued use group were younger (5588 women [42.4%] vs 4944 women [33.9%] aged &lt;30 years), less educated (4281 women [32.5%] vs 5821 women [39.9%] who completed postsecondary education or above), and more likely to have smoked in early pregnancy (1445 individuals [11.0%] vs 1180 individuals [8.1%]), been born in a non-Nordic country (1641 individuals [12.4%] vs 975 individuals [6.7%]), and used anxiolytics (1301 individuals [9.9%] vs 1119 individuals [7.7%]) and hypnotics and sedatives (1609 individuals [12.2%] vs 1510 individuals [10.4%]). Psychiatric-related hospitalizations occurred in 49 individuals (0.4%) in the discontinued vs 59 individuals (0.5%) in the continued use group in the 90 days after childbirth, with an adjusted hazard ratio (aHR) of 1.28 (95% CI, 0.85-1.91), while at 1.5 years after childbirth, the aHR was 0.81 (95% CI, 0.66-1.00). Lower hazard rates for psychiatric-related outpatient visits in the discontinued vs continued use group at 90 days (aHR, 0.59; 95% CI, 0.53-0.66) and 1.5 years (aHR, 0.60; 95% CI, 0.57-0.64) after childbirth were found. No difference in sick leave absence was found; however, individuals who discontinued had fewer days of sick leave by 1.5 years after childbirth than those who continued (mean [SD], 44.6 [70.6] days vs 53.1 [82.3] days).Conclusions and RelevanceIn this study, approximately half of pregnant women discontinued SSRIs or SNRIs, and discontinuation during pregnancy was not associated with adverse psychiatric-related outcomes, including hospitalizations, outpatient visits, suicidal behavior, or sick leave absence in the 90 days or 1.5 years after childbirth.

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Sick leave and medication use in pregnancy: a European web-based study

Cited by 21 publications

References 32 publications

Do birthrates contribute to sickness absence differences in women? A cohort study in Catalonia, Spain, 2012-2014

Do birthrates contribute to sickness absence differences in women? A cohort study in Catalonia, Spain, 2012-2014

Night work and sick leave during pregnancy: a national register-based within-worker cohort study

Postpartum Psychiatric Outcomes and Sick Leave After Discontinuing SSRI or SNRI in Pregnancy

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