Sickle cell disease: A review and update of current therapy

Lawrenz, Dietrich R

doi:10.1016/s0278-2391(99)90234-3

Cited by 20 publications

(14 citation statements)

References 21 publications

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“…Regardless of the impact of SCD on the dental tissues, the oral health of these individuals is essential to prevent dental infections that could precipitate a vaso‐occlusive crisis 36 or act as a bacterial source for development of osteomyelitis of the mandible which has lost its blood supply 37 …”

Section: Discussionmentioning

confidence: 99%

Sickle cell disease does not predispose to caries or periodontal disease

Passos¹,

Santos²,

Aguiar³

et al. 2012

Special Care in Dentistry

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This study investigated the prevalence of dental caries and periodontal condition in a population with sickle cell disease (SCD), analyzing some associations with disease severity. The Decayed, Missing and Filled Teeth index (DMFT) and Community Periodontal Index (CPI) were recorded for 99 individuals with SCD and 91 matched controls. Socio‐demographic status, oral health behaviors, and history of clinical severity of SCD were assessed. Statistical comparisons were performed between the group with SCD and the control group, as well as multivariate logistic regression analyses with DMFT index and CPI as the dependent variables. The mean number of decayed teeth was significantly higher in individuals with HbSS. Older age, female gender, and daily smoking were identified as risk factors for higher DMFT, while older age and absence of daily use of dental floss were risk factors for the development of periodontal disease. In conclusion, risk factors known to cause caries and periodontal disease had more influence on oral health than the direct impact of SCD.

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Section: Discussionmentioning

confidence: 99%

Sickle cell disease does not predispose to caries or periodontal disease

Passos¹,

Santos²,

Aguiar³

et al. 2012

Special Care in Dentistry

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“…Osteomyelitis occurs 200 times more frequently in subjects with SCD than in the general population 28 . It has been suggested 28 that this condition is preceded by a bony infarct that provides a suitable environment for the growth of bacteria from nearby infected locations, such as periapical abscesses or pericoronitis. Clinical signs such as pain, swelling, fever, and leukocytosis are similar to those of bony infarct events 18,22,28 …”

Section: Discussionmentioning

confidence: 99%

Radiographic changes of the jaws in HbSS and HbSC genotypes of sickle cell disease

Neves

Almeida

Oliveira‐Santos

et al. 2011

Special Care in Dentistry

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This study used panoramic radiographs to evaluate the presence of radiographic changes in the jaws of a population who had sickle cell disease (SCD). The authors compared the frequency of findings between subjects with and without SCD. Panoramic radiographs of 71 subjects with SCD (36 with HbSS and 35 with HbSC) and 52 healthy controls (HbAA) were evaluated for the presence of the following radiographic alterations: radiopaque areas, increased spacing of bony trabeculae, horizontal arrangement of bony trabeculae, and absence of mandibular canal corticalization. The control group had a significantly smaller number of all the radiographic features evaluated. Differences were not statistically significant between the groups with HbSS and HbSC, except for more trabecular spacing in the molar region in the HbSS genotype, suggesting a possible correlation between radiographic findings and disease presentation.

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“…Regardless of the impact of SCD on dental tissues, the oral health of these individuals is essential to prevent dental infections that could precipitate a vaso-occlusive crisis [14] or act as a bacterial source for development of osteomyelitis of the mandible, which has lost its blood supply [15]. The aim of this study was to investigate the experience of dental caries in a Brazilian pediatric population with SCD, analyzing possible associations with the history and severity of the SCD, socio-economic factors, and their impact on oral health-related quality of life (OHRQoL).…”

Section: Introductionmentioning

confidence: 99%

Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: cross-sectional study

et al. 2015

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BackgroundChildren with sickle cell disease (SCD) may present oral conditions that can compromise children's health even more. However, there is still no consensus on the association between SCD and dental caries. The aim of this study was to assess caries prevalence in children with sickle cell disease (SCD), and the association of dental caries with socioeconomic factors, disease severity, and oral-health related to quality of life (OHRQoL).MethodsThe sample was comprised of 106 children with SCD aged 8 to 14 years who were attending the Center for Hematology (Hemominas) in Belo Horizonte, Brazil. They were matched to 385 healthy peers. Data collection included interviews with guardians concerning SCD characteristics, and previous social and oral examinations to determine the caries prevalence. Caries prevalence as measured through the Decayed, Missing and Filled (dmft and DMFT) indices. OHRQoL was evaluated through the Brazilian versions of the Child Perceptions Questionnaires (CPQ8–10, and CPQ11–14 short-form version). Statistical analyses were performed using the chi-square test or Fisher`s exact test and the Mann Whitney test, as well as linear regression.ResultsThe DMFT index was 1.3 (SD: 2.1) in younger children with SCD and 1.5 (SD: 1.9) in SCD teens. Younger children with SCD had lower caries experience compared to healthy peers (p = .03). The experience of dental caries among teens with SCD was similar to healthy peers (p > 0.05). In addition, we did not see a significant difference on the mean overall scores of CPQ8–10 between SCD younger children and controls. There was no statistically significant difference in the mean overall scores of teens CPQ11-14 between SCD and the control group. Socioeconomic variables were not associated with dental caries in the participants with SCD. However, SCD severity was associated with higher DMFT indexes (p < 0.05).ConclusionsYounger children with SCD had a low experience of dental caries. The dental caries experience in teenagers with SCD was similar to their healthy peers. OHRQoL was similar between SCD participants and controls.

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Sickle cell disease: A review and update of current therapy

Cited by 20 publications

References 21 publications

Sickle cell disease does not predispose to caries or periodontal disease

Sickle cell disease does not predispose to caries or periodontal disease

Radiographic changes of the jaws in HbSS and HbSC genotypes of sickle cell disease

Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: cross-sectional study

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