Sickle cell disease and hyperparathyroidism: case report

Jridi, Maysam; Mekni, Sabrine; Meriem, Adel; Rojbi, I.; Naçef, I. Ben; Mchirgui, N.; Khiari, K.

doi:10.1530/endoabs.81.ep178

Cited by 1 publication

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“…Having both SCD and PHPT can be life-threatening for patients, and our patient's early diagnosis of PHPT suggests potentially worse long-term outcomes compared to typical presentations ( 15 ). Several studies suggest that individuals with PHPT may contribute to sickle cell crisis through the Gardos effect ( Fig.…”

Section: Discussionmentioning

confidence: 87%

Random Occurrence or Real Association? Primary Hyperparathyroidism in a Young Man With Sickle Cell Disease

Lopez Fanas,

Fouad,

Swedish

2024

JCEM Case Reports

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A 32-year-old man with sickle cell disease (SCD) was admitted to the hospital for sickle cell crisis, during which laboratory workup revealed primary hyperparathyroidism. His treatment regimen included hydration, calcitonin, and calcimimetics. A parathyroid nuclear scan revealed anomalous parathyroid tissue. The precise relationship between primary hyperparathyroidism (PHPT) and SCD remains incompletely understood but may involve factors such as vitamin D deficiency, elevated erythropoietin levels, and the influence of growth factors on the development of parathyroid adenomas. Furthermore, the concurrent occurrence of both PHPT and SCD at an earlier age may potentiate adverse long-term outcomes. Effective management of PHPT in SCD entails addressing hypercalcemia and treating the underlying cause of hyperparathyroidism. While a potential association between PHPT and SCD exists, further research is essential to better elucidate their interaction, prevalence, clinical presentations, and outcomes.

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Section: Discussionmentioning

confidence: 87%