Sickle cell disease and venous thromboembolism: A retrospective comparison of the rate of positive CT pulmonary angiography in the emergency department

Bates, ‬David D. B.; Liu, Z.; Gibbons, J.; LeBedis, Christina A.; Holalkere, Nagaraj-Setty

doi:10.1016/j.ejrad.2018.11.033

“…17 Generally, vasocculssion events related to activation of coagulation pathway and impairment of the vessels. 18 In our study FVL was completely absent in both controls and SCD patients as Only wildtype Fv (Figure 7) is dominate and this results approximately compatible with many previous studies which concluded that no significant associations between the SCA and Factor V G1691A (p=0.555). 19,20 and other studies report similar prevalence of FV Leiden in both SCD patients and normal controls (21) suggesting that inherited hyper coagulability risk factors have low impact on the pathogenesis of sickle cell disease and its complications.…”

Section: Discussionsupporting

confidence: 92%

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2020

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Background: Vascular thrombosis is an important pathophysiological aspect of sickle cell disease (SCD). This study aimed to detect the inherited risk factors FV Leiden G 1690 A and Prothrombin G 20210 A in sickle cell Anaemia patients. A total of 50blood samples collected from sickle cell disease patients in steady state. The control group consisted of 50 blood samples were collected from healthy people matched with age and gender of study subjects. All samples were investigated for PT, PTT, TT,using Semi automated STA4coagulometer. Level of D-dimer, TAT complex was estimated by ELIZA. Inherited mutations were detected by RFLP method using PCR machine TECHNE (TC-400). The study showed complete absence of FVL mutation (0) % in SCA patients in compare with prothrombin mutation which was found in (18.0%) while the frequency of two mutations in controls is (0%) Comparison of coagulation tests PT, PTT and TT between positive and negative Prothrombin G2021A mutation within the SCD patients, positive patients showed slight prolongation in mean PTT (39.1667s versus 36.6832s in negative patient paralleled with slightly higher in mean level TAT (10.57133 versus 4.94941 ng/ml) and mean level D-dimer (3541. Versus 2261.06 ng/ml). The study concluded that SCA patients exhibit chronic activation coagulation process even in steady state and moreenhanced in heterozygous prothrombin G1962A patients, cohort studies are needed to evaluate the clinical impact of prothrombin mutation on the frequency of vasoclusive crises and other complications.

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“…17 Generally, vasocculssion events related to activation of coagulation pathway and impairment of the vessels. 18 In our study FVL was completely absent in both controls and SCD patients as Only wildtype Fv (Figure 7) is dominate and this results approximately compatible with many previous studies which concluded that no significant associations between the SCA and Factor V G1691A (p=0.555). 19,20 and other studies report similar prevalence of FV Leiden in both SCD patients and normal controls (21) suggesting that inherited hyper coagulability risk factors have low impact on the pathogenesis of sickle cell disease and its complications.…”

Section: Discussionsupporting

confidence: 92%

Association of FV leiden G 1690 A and prothrombin G 20210 in coagulation activation of sudanese sickle cell anemia patients

Hussein¹,

Mohammed²,

haroon³

et al. 2020

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Background: Vascular thrombosis is an important pathophysiological aspect of sickle cell disease (SCD). This study aimed to detect the inherited risk factors FV Leiden G 1690 A and Prothrombin G 20210 A in sickle cell Anaemia patients. A total of 50blood samples collected from sickle cell disease patients in steady state. The control group consisted of 50 blood samples were collected from healthy people matched with age and gender of study subjects. All samples were investigated for PT, PTT, TT,using Semi automated STA4coagulometer. Level of D-dimer, TAT complex was estimated by ELIZA. Inherited mutations were detected by RFLP method using PCR machine TECHNE (TC-400). The study showed complete absence of FVL mutation (0) % in SCA patients in compare with prothrombin mutation which was found in (18.0%) while the frequency of two mutations in controls is (0%) Comparison of coagulation tests PT, PTT and TT between positive and negative Prothrombin G2021A mutation within the SCD patients, positive patients showed slight prolongation in mean PTT (39.1667s versus 36.6832s in negative patient paralleled with slightly higher in mean level TAT (10.57133 versus 4.94941 ng/ml) and mean level D-dimer (3541. Versus 2261.06 ng/ml). The study concluded that SCA patients exhibit chronic activation coagulation process even in steady state and moreenhanced in heterozygous prothrombin G1962A patients, cohort studies are needed to evaluate the clinical impact of prothrombin mutation on the frequency of vasoclusive crises and other complications.

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“…Elevated plasma D-dimer levels indicate increased plasmin degradation of cross-linked fibrin, and are therefore an indirect indication of increased thrombin activity and fibrin formation. Increasing of thrombin activity and fibrin formation these increasing are features of steady-state sickle cell disease, and that they further increase during painful crisis 13 . With regard to protein C and protein S, patients with SCD our study reported decreased levels in most of the patients (62% & 81%) respectively with no significant differences according to patients' state (VOC & Steady).This finding is in agreement with previous report among SCD patients 14,15 .…”

Section: Discussionmentioning

confidence: 99%

Comparative study of hypercoagulability change in steady state and during vaso-occlusive crisis among Sudanese patients living with sickle cell disease

Mohamed

¹

,

Elgari

²

,

Babker

³

et al. 2020

Afr H. Sci.

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Background: Sickle cell disease (SCD) is an inherited blood disorder that affects red blood cells. (SCD) is characterized by re- current vaso-occlusive crisis (VOC). Material and methods: This was a descriptive cross sectional study conducted through the period from July 2015 to July 2017 in which a total of seventy two blood specimens were collected in 'EDTA' and citrated vacutainers from Sudanese patients with SCD attending "Fath Elrhman Albasheer" Centre. Both sexes' with different ages were included. Among these samples 49 (68.1%) were in steady state while the remained 23 (31.9%) were in VOC. All samples were tested for coagulation profile Result: There was increase in fibrinogen and D-dimer levels in most patients 67% and 71%, respectively. Significant increase in D-dimers was observed in patients with (VOC) compared with steady state (P. value = 0.006). Protein S was significantly in- creased in males in comparison with females P. value = 0.017. The results of prothrombin time (PT), international normalized ratio (INR) and thrombin time (TT) were within normal range. Conclusion: Significant increase in levels of D-dimer during VOC indicating abnormal coagulation and fibrinolysis activation. Reduced levels of natural anticoagulants proteins C and S can be consider as predictive markers indicate hepatic dysfunction in patients with SCD. Keyword: SCD; VOC; hypercoagulability; Sudanese patients.

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Sickle cell disease and venous thromboembolism: A retrospective comparison of the rate of positive CT pulmonary angiography in the emergency department

Cited by 7 publications

References 23 publications

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Association of FV leiden G 1690 A and prothrombin G 20210 in coagulation activation of sudanese sickle cell anemia patients

Comparative study of hypercoagulability change in steady state and during vaso-occlusive crisis among Sudanese patients living with sickle cell disease

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