Sickle Cell Disease in Nigeria -----------A Review

Emechebe, GO; Onyire, NB; Ml, Orji; Achigbu, KI

doi:10.9790/0853-1601048794

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…However, some empirical studies have shown that general attitudinal disposition by individuals and government, means of SCD communication intervention, the influence of finance and religious beliefs in the pre-marital decision are major factors that have contributed in the persistence of the disease in sub-Saharan Africa and more especially Nigeria (Makani, Williams, & Marsh 2017;Jiya et al, 2017;Patrick, Mc Gann. Ariell, Hermandez, & Russal, 2018;Emechebe, Onyire, Orji, & Achigbu, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…The public trust on the mass media has empowered them to detect what is important to the modern society through various media activities such as information dissemination, mobilization, advertisement, publicity, education and entertainment etc (Ikachoi, 2012). Since research has shown that Nigeria bears the highest burden of the disease (World Health Organisation [WHO], 2006;Jiya, Umar, Ibrahim, Mohammed, Erhabor, Mainasara, Ndakotsu, Garba, & Musa, 2017;Emechebe, Onyire, Orji, & Achigbu, 2017;Adewoyin, Alagba, Adedokun, & Idubor, 2015;Allege, 2015), one could decide to ask the following questions.…”

Section: Introductionmentioning

confidence: 99%

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The Potential Impact of Mass Media Education in the Psycho-Social Life and Epidemiology of Sickle Cell Disease in Nigeria

Okere¹,

Morka²

2020

GJHS

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The lack of public awareness and education is the greatest challenge in the fight against Sickle Disease (SCD) in Nigeria. The sufferers of the disease experience debilitating pains, psychological challenges, stigmatization and as a result many have very poor social life style. What enduring step, has the mass media, as a reliable societal medium taken to address the spread of SCD? No serious attention has been given to the use of media technology in the education of the masses on the risk factors of SCD. The mass media has a key role to play in the treatment and management of SCD in Nigeria.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Potential Impact of Mass Media Education in the Psycho-Social Life and Epidemiology of Sickle Cell Disease in Nigeria

Okere¹,

Morka²

2020

GJHS

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“…The term sickle cell disease (SCD) is used when the hemoglobin (Hb) S gene alone or in conjunction with another abnormal beta (β) globulin gene has been inherited by an individual. A substitution of a single amino acid in the beta globulin chain of the adult hemoglobin molecule, results in the formation of either hemoglobin S, C, D, or E depending on amino acid substitution [5,6]. Sickle cell anemia (SCA) is a homozygous state caused by a point mutation in the beta globulin gene in which glutamic acid is replaced by valine at the sixth position, resulting in the synthesis of a variant of hemoglobin known as hemoglobin S (HbS) which is a structural variant of the normal adult hemoglobin (HbA) [5].…”

Section: Introductionmentioning

confidence: 99%

“…A substitution of a single amino acid in the beta globulin chain of the adult hemoglobin molecule, results in the formation of either hemoglobin S, C, D, or E depending on amino acid substitution [5,6]. Sickle cell anemia (SCA) is a homozygous state caused by a point mutation in the beta globulin gene in which glutamic acid is replaced by valine at the sixth position, resulting in the synthesis of a variant of hemoglobin known as hemoglobin S (HbS) which is a structural variant of the normal adult hemoglobin (HbA) [5]. At low oxygen tension, HbS polymerizes in the red blood cells [7,8] which makes the erythrocyte membranes more rigid.…”

Section: Introductionmentioning

confidence: 99%

Sickle Cell Disease Complications and BMI Percentiles of Pediatric Patients

Alaka,

Iyanda

2024

AJMAH

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BMI percentile is a good index of nutritional status among pediatric patients. Yet there is a dearth of information about the relationship between this important anthropometric parameter and specific severity indices among pediatric patients. The study is designed to explore the possibility of such a relationship. Methods: Pediatric study participants were divided into test [HbSS, HbSC] and control [HbAA] groups. The questionnaire was administered to obtain information on age, gender, and clinical features of the disease [pain frequency, leg ulcer, priapism]. The anthropometry indices were determined. BMI as well as BMI percentiles were calculated. Data were summarized using relative frequency, mean, and standard deviation while analysis of variance, LSD post hoc tests and Chi‑squared tests were used for inferential statistics. Significant levels were set with P < 0.05. Results: There were significant differences in the body weight, height and BMI of HbAA, HbSC and HbSS. The distribution of the BMI percentiles for the three genotypes showed that 5% of HbAA, 20% of HbSC, and 35.7% of HbSS were in unhealthy categories. The occurrence of leg ulcers and priapism among the two SCD genotypes was 0% and 3.57% respectively. The Chi-square tests showed a significant difference between BMI percentiles (X2=72.51; P=<.001) or painful episodes (X2=15.992; P=.003) and hemoglobin genotypes [HbSS, HbSC]. Among SCD patients there was a relationship between BMI percentiles and pain frequency (X2=50.59; P=<.001). Conclusion: The study suggests that SCD impacts BMI percentiles. Also, the frequency of occurrence of priapism and leg ulcers varied widely, indicating that priapism among the SCD patients may be a more common SCD complication than leg ulcer in the region. The fact that there was a higher frequency of pain among HbSS than HbSC suggests a bias in distribution of pain frequency in the 2 hemoglobinopathies.

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“…Nearly 90 percent of the world's SCD population lives in three countries: Nigeria, India, and the Democratic Republic of Congo, where the disease affects up to 2 percent of the population, and the carrier prevalence rate [sickle cell trait] is as high as 10 to 30 percent [11,12]. Nigeria alone has been estimated to have at least 150,000 newborns born with SCD annually.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of Sickle Cell Disease among University Students in Port Harcourt

Tamuno-Opubo

Oluchi

Ibekwe

et al. 2020

IBRR

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Background: Sickle Cell Disease (SCD) is a hereditary haemoglobinopathy that has been related with significant mortality in Nigeria. Knowledge on cause, prevention and risk factors are important for adequate control of the occurrence of SCD. Methods: A cross sectional study on the awareness of SCD was carried out among undergraduate students in Port Harcourt, Nigeria. A structured questionnaire was interviewer-administered to 146 students. Results: The study showed that 97.9% claim to have heard about sickle cell, while 68.5% indicated that the source of information on sickle cell was in school. One hundred and twenty-seven (87%) indicated that SCD describes abnormal blood cells. In 68.5% the source of information on SCD was in school. Only 42% had a good awareness on SCD. Students of male gender, of less than 20 years, with less average family income were more likely to have poor awareness of SCD. Conclusion: The study shows the need for improved awareness on SCD and increased awareness campaigns on every available media platform.

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Sickle Cell Disease in Nigeria -----------A Review

Cited by 8 publications

References 26 publications

The Potential Impact of Mass Media Education in the Psycho-Social Life and Epidemiology of Sickle Cell Disease in Nigeria

The Potential Impact of Mass Media Education in the Psycho-Social Life and Epidemiology of Sickle Cell Disease in Nigeria

Sickle Cell Disease Complications and BMI Percentiles of Pediatric Patients

Knowledge of Sickle Cell Disease among University Students in Port Harcourt

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