2013
DOI: 10.1038/gim.2012.128
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Sickle cell disease incidence among newborns in New York State by maternal race/ethnicity and nativity

Abstract: Purpose Sickle cell disease is estimated to occur in 1:300–400 African-American births, with higher rates among immigrants from Africa and the Caribbean, and is less common among Hispanic births. This study determined sickle cell disease incidence among New York State newborns stratified by maternal race/ethnicity and nativity. Methods Newborns with confirmed sickle cell disease born to New York State residents were identified by the New York State newborn screening program for the years 2000–2008 and matche… Show more

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Cited by 38 publications
(41 citation statements)
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“…Similar to previous reports, the birth prevalence of SCD has remained stable at 17.4 per 100 000 screened, affecting 1 : 350 Black births and 1 : 2560 Hispanic births [5,6]. These figures parallel those recently reported in New York state, citing annual incidence rates for SCD of 1 : 230 non-Hispanic Black births and 1 : 2320 Hispanic births [7].…”
Section: Epidemiologysupporting
confidence: 87%
“…Similar to previous reports, the birth prevalence of SCD has remained stable at 17.4 per 100 000 screened, affecting 1 : 350 Black births and 1 : 2560 Hispanic births [5,6]. These figures parallel those recently reported in New York state, citing annual incidence rates for SCD of 1 : 230 non-Hispanic Black births and 1 : 2320 Hispanic births [7].…”
Section: Epidemiologysupporting
confidence: 87%
“…National and state‐specific prevalence estimates for African American and Hispanic populations (Table ) were based on records from the National Newborn Screening Information System (NNSIS) for 2005–2007 for all 50 states and territories, the New York State newborn screening program for the years 2000–2008, and the Registry and Surveillance System for Hemoglobinopathies (RuSH) for 2004–2008 . Table provides U.S. SCD population and prevalence estimates, highlighting the substantial numbers of affected Hispanic newborns across the U.S.…”
Section: Resultsmentioning
confidence: 99%
“…Latino sickle cell in the U.S. National and state-specific prevalence estimates for African American and Hispanic populations (Table I) Table I provides U.S. SCD population and prevalence estimates, highlighting the substantial numbers of affected Hispanic newborns across the U.S. Regional variation for Latino SCD reflects considerable differences in prevalence between Latino communities [1,10,23]. Low rates of SCD and sickle trait in U.S. newborns of Mexican ancestry are consistent with low prevalence rates reported from Mexico [17].…”
Section: Demographicsmentioning
confidence: 99%
“…These perceptions may be mirroring Mendelian disorders which often vary among populations. Well known examples of Mendelian disorders whose risk varies by race include cystic fibrosis, which is more common in people of Northern European descent [54], and sickle cell trait, which is more common in people of African and Mediterranean descent [55]. Demographic characteristics such as race and ethnicity serve as loose proxies for capturing these types of subpopulation variation and may very well play a significant role in probing environmental and genetic routes of diseases [1,9,56,57].…”
Section: Discussionmentioning
confidence: 99%