Sickle Cell Disease Pathophysiology and Related Molecular and Biophysical Biomarkers

Saah, Elna; Fadaei, Payam; Gürkan, Umut A.; Sheehan, Vivien A.

doi:10.1016/j.hoc.2022.06.005

Cited by 7 publications

(1 citation statement)

References 110 publications

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“…Recently, Saah et al . summarized the challenge to identify and validate prognostic biomarkers to assess an individual’s risk of specific clinical complications 12 . Here, we propose a specific biomarker to assess VOC risk.…”

Section: Discussionmentioning

confidence: 99%

Lactate dehydrogenase and hemolysis index to predict vaso-occlusive crisis in sickle cell disease

Feugray,

Dumesnil,

Grall

et al. 2023

Sci Rep

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Sickle cell disease (SCD) is an inherited hemoglobinopathy disorder associated with chronic hemolysis. A major complication is vaso-occlusive crisis (VOC), associating frequent hospitalization, morbidity and mortality. The aim of this study was to investigate whether hemolysis biomarkers were able to predict VOC risk in adult patients with SCD requiring hospitalization within 1 year. This single-center prospective study included adult patients with SCD at steady state or during VOC. A total of 182 patients with SCD were included, 151 at steady state and 31 during VOC. Among the 151 patients at steady state 41 experienced VOC within 1 year (median: 3.0 months [2.0–6.5]). We observed an increase of lactate dehydrogenase (LDH) (p = 0.01) and hemolysis index (HI) (p = 0.0043) during VOC compared to steady state. Regarding patients with VOC requiring hospitalization, LDH (p = 0.0073) and HI (p = 0.04) were increased. In unadjusted logistic regression, LDH > median (> 260 U/L) (RR = 3.6 [1.29–10.88], p = 0.0098) and HI > median (> 8 UA/L) (RR = 3.13 [1.91–5.33]; p < 0.001) were associated with VOC. The association of LDH > 260 U/L and HI > 12 UA/L presented a sensitivity of 90%, and a specificity of 72.9% to predict VOC. The association of LDH and HI cut-off was able to predict VOC risk in SCD.

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Section: Discussionmentioning

confidence: 99%