Sickle cell heart disease. Two-dimensional echo and Doppler ultrasonographic findings in the hearts of adult patients with sickle cell anemia

Simmons, Brian E.; Santhanam, Vimala; Castañer, Angel; Rao, Koduri R. P.; Sachdev, Naveen; Cooper, Richard

doi:10.1001/archinte.148.7.1526

Cited by 55 publications

(56 citation statements)

References 22 publications

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“…These results were not found in patients under 20 years of age 12 . Although this patient showed no abnormalities in the echocardiogram at rest, cardiovascular abnormalities are consistently reported in the literature 13 . An important correlation with pulmonary hypertension, enlargement of the left chambers and LV mass indexes are also encountered.…”

Section: Discussionsupporting

confidence: 52%

Myocardial bridge in a patient with sickle cell anemia

Seixas¹,

Junior²,

Silva³

et al. 1999

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 52%

Myocardial bridge in a patient with sickle cell anemia

Seixas¹,

Junior²,

Silva³

et al. 1999

Arq. Bras. Cardiol.

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“…[24][25][26][27] PXE has furthermore been related to MVP, 28 a high occurrence of which has also been reported in ␤-thalassemia 29 and sickle cell disease, 30 though it is questioned in the latter. 31 We did not find a high incidence of MVP in our patients with TI (5.4%); we used, however, the most recent diagnostic criteria for MVP. 9 These criteria are more stringent than those used in previous studies, in which a prevalence ranging widely between 5% and 35% are reported in healthy controls.…”

Section: Pericardial and Valvular Disordersmentioning

confidence: 64%

Cardiac involvement in thalassemia intermedia: a multicenter study

Aessopos

Farmakis

Karagiorga

et al. 2001

Blood

259

261

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Cardiac complications in 110 patients (mean age, 32.5 ؎ 11.4 years) with thalassemia intermedia (TI) were studied. Sixtyseven (60.9%) of them had not been transfused or were minimally transfused (group A). The rest had started transfusions after the age of 5 years (mean, 15.1 ؎ 10.1 years), initially on demand and later more frequently (group B). Overall mean hemoglobin and ferritin levels were 9.1 ؎ 1.1 g/dL and 1657 ؎ 1477 ng/mL, respectively. Seventy-six healthy controls were also studied. The investigation included thorough history taking, clinical examination, electrocardiography, chest radiograph, and full resting echocardiography. Of 110 patients, 6 (5.4%) had congestive heart failure (CHF), and 9 (8.1%) had a history of acute pericarditis. Echocardiography showed pericardial thickening, with or without effusion, in 34.5% of the patients.

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“…Simmons and colleagues, for example, using Doppler criteria, reported pulmonary hypertension in 63% of 40 adult patients with SCD [2]. Gladwin and colleagues found pulmonary hypertension in 34% of 154 patients with SCD, whereas severe pulmonary hypertension was noted in 9% patients [17].…”

Section: Discussionmentioning

confidence: 99%

“…The cardiovascular complications of sickle cell disease (SCD) are being recognized more often and include cardiac enlargement, myocardial ischemia, biventricular dysfunction, and pulmonary hypertension among others [1][2][3][4][5]. Cardiovascular manifestations of SCD have been attributed to chronic hemolytic anemia, which is typically found in this disorder [6,7].…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic abnormalities in sickle cell disease

et al. 2004

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Echocardiographic abnormalities in patients with sickle cell disease (SCD) were determined, and pulmonary arterial systolic pressure (PASP) was estimated. Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact test was performed to determine correlation between pulmonary hypertension and various clinical variables. Pulmonary hypertension was the most common abnormality identified in 22 (58%) patients. The estimated mean PASP was 37.5¯± 10.9 mmHg. Older age and prior history of acute chest syndrome were significantly correlated with an increased prevalence of pulmonary hypertension (P < 0.05). Patients with hemoglobin levels <8 g/dL had PASP 43.2¯± 0.5 compared to a mean PASP of 33.3¯± 6.0 in patients with hemoglobin ‡8 g/dL (P = 0.01). Eight (21%) patients had evidence of a hyperdynamic left ventricle. Left heart abnormalities included dilated atrium in 14 (37%), dilated ventricle in 5 (13%), ventricle hypertrophy in 5 (13%), and ventricle dysfunction in 3 (9%) patients. Right heart abnormalities included dilated atrium in 9 (24%), dilated ventricle in 6 (16%), and ventricle dysfunction in 3 (9%) patients. Despite an increased incidence of abnormal flow across the valves on Doppler analysis, no patient had structurally abnormal valves. A majority of patients with SCD had evidence of pulmonary hypertension, which correlated with older age and history of acute chest syndrome. Other structural and functional echocardiographic abnormalities were less common. Am.

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Sickle cell heart disease. Two-dimensional echo and Doppler ultrasonographic findings in the hearts of adult patients with sickle cell anemia

Cited by 55 publications

References 22 publications

Myocardial bridge in a patient with sickle cell anemia

Myocardial bridge in a patient with sickle cell anemia

Cardiac involvement in thalassemia intermedia: a multicenter study

Echocardiographic abnormalities in sickle cell disease

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