Sickle Cell Patient and Addiction to Tramadol: Case Management in Senegal

Sy, Abou; Tine, Jean Augustin Diégane; Benmansour, Safiyah; Mamadou, Samba Oumar; Binta, Ba; Diallo, Aissatou; Sheikh, Taiwo Lateef; Habib, Thiam Mamadou

doi:10.4236/health.2020.122008

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…The fourth category pertains to students in both public and private schools in rural and urban areas, including secondary school students aged 13–18, upper secondary school students, and graduate or undergraduate university students [ 10 , 72 , 84 – 105 ]. The final group includes non-traditional populations, such as indigenous communities [ 17 ], teenagers attending summer camps [ 106 ], internally displaced [ 107 ] and various people [ 11 , 18 , 108 – 110 ].…”

Section: Resultsmentioning

confidence: 99%

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Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

Boun,

Omonaiye,

Yaya

2024

PLOS Glob Public Health

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Tramadol is a widely prescribed painkiller around the world. As a synthetic opioid, it offers a valuable substitute for morphine and its derivatives in African countries. However, the adverse health effects of tramadol use resulting from illicit trafficking, like those caused by fentanyl and methadone in North America, have not been well-documented in Africa. This scoping review aims to shed light on the nature and scope of the nonmedical use (NMU) of tramadol in Africa and its associated health consequences. To carry out our scoping review, we used Arksey and O’Malley’s (2005) five-step approach for exploratory analysis and followed Joanna Briggs Institute guidelines for scoping reviews to ensure systematic and replicable studies. We then searched six databases: Medline, Global Health (EBSCO), Scopus, Web of Science, the African Journals online database, and for grey literature via Google Scholar without any time restriction. The articles were imported into Covidence and reviewed by two independent researchers. Eighty-three studies on NMU of tramadol’s prevalence or health consequences were selected from 532 titles/abstracts screened, including 60 cross-sectional and six qualitative studies from 10 African countries. Findings from the included studies highlighted five distinct groups significantly affected by the NMU of tramadol. These groups include: 1) young adults/active populations with varying degrees of prevalence ranging from 1.9% to 77.04%, 2) professionals, where drivers exhibit a relatively high prevalence of tramadol NMU, ranging from 7.2% to 35.1%, and commercial motorcyclists, with a prevalence of 76%, 3) patients, who have a high rate of tramadol NMUs, with prevalence rates ranging from 77.1% to 92%, 4) academics, with a considerable rate of tramadol misuse among substance-using undergraduates (74.2%) and substance-using high school students (83.3%), and 5) other individuals impacted in various ways. The health consequences are classified into four distinct types: intoxication, dependence syndrome, withdrawal syndrome and other symptoms. Despite providing a comprehensive global overview of the phenomenon described in the African literature, this systematic scoping review’s main limitations stem from the relatively limited exploration of various consequences of the NMU of tramadol, notably those of a social and economic nature. Our review shows that tramadol misuse affects diverse populations in Africa. The prevalence of misuse varies within sub-populations, indicating the complexity of the issue. Professional and academic groups have different rates of misuse across regions. This highlights the need for targeted interventions to address unique challenges contributing to tramadol misuse. Future studies should focus on the social and economic costs of abuse on households to better understand the impact on well-being. Systematic review registration: Open Science Framework: https://osf.io/ykt25/.

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Section: Resultsmentioning

confidence: 99%

“…These symptoms can include sleep disturbances such as insomnia [ 60 , 110 ], physical symptoms like severe pain, craving and fatigue, palpitations, and tremors [ 110 ], as well as emotional and behavioural symptoms such as irritability, anxiety, depression, attention disorders and emotional aloofness [ 50 , 63 , 109 ].…”

Section: Resultsmentioning

confidence: 99%

Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

Boun,

Omonaiye,

Yaya

2024

PLOS Glob Public Health

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Quality Control of Tramadol in Kisangani: Development, Validation, and Application of a UV-Vis Spectroscopic Method

Amani¹,

Kindenge²,

Baruti³

et al. 2021

AJAC

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Context: Substandard and falsified medicines are circulating in low-income countries mostly without any control. We availed a simple and not expensive UV-Vis spectroscopic method to evaluate the quality of tramadol in Kisangani before and during the Covid-19 period. Methods: For the analytical quantitative method, an experimental design was applied to set up the optimal levels of the selected factors, namely, pH of dissolution medium, type of cuvette, and wavelength. Taking into account the capsule pharmaceutical formulation within 80 -120 µg•mL −1 concentration range, we analyzed 89 tramadol samples from pharmacies and hospitals of the six Kisangani municipalities. Results: pH showed a significant effect on absorbance, whereas quartz cuvette and wavelength did not. A typical 100 µg•mL −1 tramadol solution gave an absorbance of 0.64 at 272 nm. Validation highlighted a matrix effect observed with a 6% bias. A correction factor of 0.9372 allowed to improve the accuracy profile, which were then totally included within the 10% acceptance limits. Quality control revealed that 25 samples out of 89 were not compliant in terms of manufacturing license, registration status in DRC and content as well. Conclusion: This study showed that the strengthening of analytical strategy in Kisangani is a need.

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Sickle Cell Patient and Addiction to Tramadol: Case Management in Senegal

Cited by 2 publications

References 8 publications

Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

Quality Control of Tramadol in Kisangani: Development, Validation, and Application of a UV-Vis Spectroscopic Method

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