Sickle-cell Rates in Kenya and the Southern Sudan

Prevalence of transcranial Doppler abnormalities in Nigerian children with sickle cell disease

“…The median number of liver laboratory evaluations (LLEs) per patient during follow-up was 3 (range: [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], with a median time between the first and last LLE of 3.6 years (range: 1 month to 30 years).…”

“…Our findings are at variance with the report from Kenya [13] in which only 3 (2.8%) of the 105 children with sickle cell anaemia (SCA) studied had CR velocities and none had abnormal velocities. The reasons for this disparity are uncertain particularly as the Bantu haplotype which is associated with low levels of hemoglobin F and severe manifestations of SCA is known to be predominant in Kenya while the relatively less severe Benin haplotype predominates in Nigeria [20,21].…”

Two Lessons From the Interface of Genetics and Medicine

“…Potentially lethal forms of principal determinant of high sickle-cell frequencies. In contrast, Lehmann (1954) and Foy et al (1954) promalaria (usually cerebral malaria or severe anemia) nearly always occur in children with high parasitemia posed that high sickle-cell frequencies in East Africa resulted from migrations of people from southern India (Field 1949;Greenwood et al 1991). From school age to adulthood, Africans living in hyperendemic areas and Arabia.…”

Nasopharyngeal Cancer in Kenya

“…It is possible that the high incidence of the lymphoma of African children and of nasopharyngeal carcinoma in adults is influenced by genetic factors. Foy, Kondi, Timms, Brass and Bushra (1954) reported considerable variation in the incidence of sickle cell trait and the distribution of ABO blood groups among East and Central Africans, and suggested that genetic drift might be an important factor in tribes which were virtually isolated genetically-marriage being almost entirely confined to the tribal group. It is not known whether this factor could operate among the Chinese, or whether marriage within a small group is more common in Southern than Northern China.…”