2022
DOI: 10.1136/tsaco-2022-000955
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Sickle cell trait and multisystem trauma: an unaddressed urgent knowledge gap

Abstract: Sickle cell trait (SCT) has historically been considered a benign condition, but SCT-positive patients have increased baseline risk of venous thromboembolism and chronic kidney disease, as well as increased risk of sickled erythrocytes in settings of hypoxia, acidosis, and hypovolemia. Multisystem traumatic injuries are a common clinical scenario, in which hypoxia, acidosis, and hypovolemia occur; however, little is known about how SCT-positive status impacts outcomes in multisystem trauma. We conducted a scop… Show more

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Cited by 3 publications
(4 citation statements)
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“…Clinical outcomes for patients with SCD with injuries are unknown due to a knowledge gap in the current literature; 16 this is especially concerning, as SCD generally impacts quality of life in African American and Hispanic communities. 32 Although our findings are preliminary, they highlight a substantial intersection between traumatic injury and heightened risk of poor VOE outcomes.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Clinical outcomes for patients with SCD with injuries are unknown due to a knowledge gap in the current literature; 16 this is especially concerning, as SCD generally impacts quality of life in African American and Hispanic communities. 32 Although our findings are preliminary, they highlight a substantial intersection between traumatic injury and heightened risk of poor VOE outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…3 15 Consequently, patients with SCD, most of whom are of African descent, represent a vulnerable population that may respond to and recover differently from traumatic injury compared with those without SCD. Yet, there is a dearth of research on the prevalence and clinical impact of traumatic injury among patients with SCD; 16 the extant literature is limited to case reports of such potential association among specific populations (eg, infants and victims of homicide). 17 18 TTA based on trauma triage protocol and inpatient admission drastically improve both in-hospital and 1 year mortality and minimize future risk of secondary complications or disability among injured patients.…”
Section: Open Accessmentioning
confidence: 99%
“…[5][6][7] Sickling of RBCs from an individual with SCT may occur when stressed with hypoxic, acidic, or low-plasma volume conditions. 8,9 Additional evidence suggests that SCT associates with increased risk of venous thromboembolism and chronic kidney disease. [10][11][12] Transfusion standards have historically favored the use of SCTnegative blood for certain recipients but the specifics of these policies are ultimately left to the discretion of individual hospital transfusion services.…”
Section: Introductionmentioning
confidence: 99%
“…Unlike individuals with SCD, carriers of a single copy of the hemoglobin beta sickle allele, that is, SCT, are eligible blood donors 5–7 . Sickling of RBCs from an individual with SCT may occur when stressed with hypoxic, acidic, or low‐plasma volume conditions 8,9 . Additional evidence suggests that SCT associates with increased risk of venous thromboembolism and chronic kidney disease 10–12 .…”
Section: Introductionmentioning
confidence: 99%