2020
DOI: 10.1111/ejh.13478
|View full text |Cite
|
Sign up to set email alerts
|

Sickle cell trait and the potential risk of severe coronavirus disease 2019—A mini‐review

Abstract: Following the emergence of Coronavirus Disease 2019 (COVID-19) in Wuhan (China) around December 2019, 1 the infection has become a pandemic, decimating over three hundred thousand globally. 2 The severity of COVID-19 cases reported hitherto has varied greatly from asymptomatic to severe pneumonia and thromboembolism, accompanied by overt respiratory failure with subsequent mortality. 3-5 As the COVID-19 pandemic continues to evolve, potential risk factors that may predispose individuals to fatal outcomes are i… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
29
0

Year Published

2020
2020
2022
2022

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 24 publications
(30 citation statements)
references
References 70 publications
(99 reference statements)
1
29
0
Order By: Relevance
“…Higher odds of VTE among Black patients has been reported previously [ 7 ]. A possible explanation for this is that Black patients have a greater prevalence of comorbidities such as obesity, hypertension and diabetes, and may have sickle cell trait [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…Higher odds of VTE among Black patients has been reported previously [ 7 ]. A possible explanation for this is that Black patients have a greater prevalence of comorbidities such as obesity, hypertension and diabetes, and may have sickle cell trait [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…No literature to date has demonstrated the potential role of sickle cell trait in complications related to COVID-19 pneumonia. Although the increased mortality rates of COVID-19 in the African-American community has been attributed to socio-economic determinants of health, the role of genetic and environmental factors such as sickle cell trait has also been suggested as a possible contributor [ 7 ]. Hypoxia-triggered conditions have occurred in patients with sickle cell trait, such as exertional rhabdomyolysis, thromboembolism, and splenic infarction [ 10 , 11 ].…”
Section: Discussionmentioning
confidence: 99%
“…The exact role of sickle cell trait as a risk factor is unclear. One recent review article suggested that COVID-19 pneumonia associated with increased oxygen demands can trigger sickle-related complications in patients with sickle cell trait [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, a study conducted by Chen et al has been demonstrated that severe cases of COVID-19 have higher levels of ferritin, C reactive protein, lactate dehydrogenase, ALT, AST, and D-dimer in addition to the cytokines including IL6, IL10, tumor necrosis factor-alpha (TNF-alpha) and IL2 receptor antagonist (IL-2RA) [ 53 ]. Additionally, the decrease in platelet count and having the genetic profile of sickle cell trait can have very high prognostic value in patients affected by SARS-CoV-2 [ 54 ].…”
Section: Approaches Of Personalized Medicine and Its Current Candidatmentioning
confidence: 99%