Sickle Cell Trait: What Every Nurse Practitioner Should Know

Benenson, Irina; Porter, Sallie; Vitale, Tracy R.

doi:10.1016/j.nurpra.2018.07.020

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Theoretically, sickle cell traits, also known as sickle cell carrier genes, are transmitted from parents to offspring [4]. When two partners carrying the trait decide to produce, there is a 25% probability of producing a sickle cell-diseased child in each pregnancy; the chances double when one partner is sickle-celled, and the other is a carrier [5].…”

Section: Introductionmentioning

confidence: 99%

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Dilli,

Obeagu,

Tamale

et al. 2024

BMC Public Health

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Background Screening for sickle cell traits before marriage or producing children is one of the outstanding preventive measures for sickle cell disease (SCD).The disease is a collection of inherited blood disorders that impact millions globally, with a predominant 75% occurrence in the sub-Saharan region. With increasing burden of SCD on the continent amidst a cost effective prevention method, no study has systematically reviewed or presented meta-analytic uptake or practice of premarital sickle cell trait screening. Methods This review systematically explored the uptake or practice of premarital genotype screening in Africa. We searched PubMed and Scopus databases for African studies on premarital screening for sickle cell traits. Results Our results indicate that the pooled uptake of premarital sickle cell trait screening in Africa is 47.82% (95% CI: [46.53–49.11]; I2: 98.95% [98.74–99.13]). Our review observed, a significant relationship between the awareness of sickle cell disease and the uptake of genotype screening; F(1, 13) = 12.04, p = 0.004). The model explained approximately 48.08% of the variation in genotype screening (R² = 0.4808) and predicted a 0.729 increase in the likelihood of genotype screening uptake for every unit rise in sickle cell disease awareness (β = 0.729, p = 0.004). Additionally, Pearson correlation (r = 0.6934) indicated a moderately strong positive correlation between the two variables. Conclusion With over 75% of the global burden of sickle cell disease domiciled in Africa, the continent cannot overlook the cost of hemoglobinopathies. The uptake of sickle cell traits screening is suboptimal across the continent. To achieve the mandate of sustainable development goal number (3); to end preventable deaths of newborns and children under 5 years of age by 2030, there is need to intensify campaigns on premarital genetic screening through education and other health promotion tools.

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Section: Introductionmentioning

confidence: 99%

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Dilli,

Obeagu,

Tamale

et al. 2024

BMC Public Health

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Pregnancy-Related Thromboembolismin Sickle Cell Disease

AlDallal

2020

EMJ Hematol

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Haematological disorders are predominant in the tropical and subtropical countries where major problems of sickle-cell disease (SCD) and thalassaemias are often recorded. However, reports of these conditions have increased in the Western hemisphere more recently. Genetic counselling, early detection of the disease condition, and determining an appropriate treatment regimen remains the solution. Most molecular types of SCD have been determined and the pathological impact of individual types along with the degree of severity is known to clinical investigators and physicians. There is, however, a significant need for a proper counselling system for the clinical diagnosis in most countries. Lack of funding, trained personnel, relevant physicians, instruments, and laboratories are the challenges to overcome. Pregnancy-associated SCD and thromboembolism require special mention due to their mortality rate, complexity of treatment, and care necessities. This review considers some of the most important aspects of pregnancy-associated SCD and thromboembolism, shedding light on the present understanding of the disease condition, pathology, clinical issues, the association with venous thromboembolism, recent treatment measures, and clinical and social management of pregnant women and fetuses for patients with SCD. Integrated social and clinical care along with extensive timely medical and clinical counselling for patients can improve the present situation which is growing in different countries. To save future generations and pregnant mothers from the haematological disorders that could be either prevented or treated, essential genetic screening or counselling should be made a priority by governments. In addition, social education and campaigns related to the disease condition can help to improve the situation.

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Sickle Cell Trait: What Every Nurse Practitioner Should Know

Cited by 2 publications

References 18 publications

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

Pregnancy-Related Thromboembolismin Sickle Cell Disease

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