Side-channel photonic crystal fiber for surface enhanced Raman scattering sensing

Zhang, Nan; Humbert, Georges; Gong, Tianxun; Shum, Perry Ping; Li, Kaiwei; Auguste, Jean‐Louis; Wu, Zhifang; Hu, Dora Juan Juan; Luan, Feng; Dinh, Xuan Quyen; Olivo, Malini; Wei, Lei

doi:10.1016/j.snb.2015.09.087

Cited by 62 publications

(47 citation statements)

References 42 publications

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“…Zhang et al designed, fabricated and characterized a solid‐core SC‐PCF which has a large side‐channel in lattice cladding for SERS sensing applications. A LOD of 50fM R6G solution was achieved . They also theoretically explore the dependence of SERS intensity on fibre length in backward scattering scheme to give guidelines in constructing high sensitivity, easy handling and versatile PCF‐based SERS optofluidic sensors.…”

Section: Major Categories Of Optical Fibres In Raman Spectroscopymentioning

confidence: 99%

Review of optical fibre probes for enhanced Raman sensing

Wang

Zeng

et al. 2017

J Raman Spectroscopy

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Raman scattering is a photon‐molecular interaction based on the kinetic modes of an analyte. It offers unique fingerprint‐type signals that allow molecular identification. A serious challenge frequently encountered in Raman measurements arises from the requirements of fast, real‐time remote sensing, fluorescence suppression, ultra‐micro concentration detection, small sample volumes and label‐free biological specimens. This review focuses on fibre‐optic probes for Raman spectroscopy, especially for enhanced sampling applications. It aims at providing an overview over contemporary technology and recent excellent researches, and helps identifying future developments necessary to bring the emerging technology to instrument manufacturers and end users. After a short introduction to surface‐enhanced Raman scattering technology, professional algorithms for design optimization of the fibre Raman probe will be discussed and general design considerations presented. Subsequently, various common geometries employed for enhanced Raman sampling are enumerated based on the types of waveguide fibres: multi‐fibre optodes, long‐pathlength capillary, microstructured photonic crystal fibre and other waveguide arrangements. Additionally, the relevant detection parameters are reviewed, such as target analyte, limit of detection, waveguide media and detection principle. The review also includes a brief summary of the advantages and limitations of various fibre Raman probes. Finally, the future work is discussed which will promote the reliability and the applicability of fibre enhanced Raman sensors. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Major Categories Of Optical Fibres In Raman Spectroscopymentioning

confidence: 99%

Review of optical fibre probes for enhanced Raman sensing

Wang

Zeng

et al. 2017

J Raman Spectroscopy

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“…Finally, in 2015 Gong et al. proposed the use of the so‐called “side‐channel SC‐PCF” as a valuable alternative to liquid‐filled HC‐PCFs for the development of highly sensitive SERS bioprobes . A side‐channel PCF is realized by removing a portion (1/6 or 1/3) of the cladding air holes (∼25 μm) from a standard SC‐PCF (with core diameter ∼3 μm and triangular lattice of air holes with pitch ∼3.1 μm) before performing the stack and draw fabrication process.…”

Section: Lab In Fibermentioning

confidence: 99%

“…A side‐channel PCF is realized by removing a portion (1/6 or 1/3) of the cladding air holes (∼25 μm) from a standard SC‐PCF (with core diameter ∼3 μm and triangular lattice of air holes with pitch ∼3.1 μm) before performing the stack and draw fabrication process. The presence of a big side‐channel within the cladding structure is able to provide several advantages with respect to standard SC‐PCF: i) it speeds up the liquid samples loading within the PCF, useful for real time applications; ii) it provides an enlargement of the effective interaction area between the target analyte and the light propagating through the solid core; iii) increases the evanescent field portion within the cladding air holes; iv) its design can be carried out to achieve low transmission losses, thus increasing the evanescent wave interaction length . Indeed, compared to HC‐PCFs, which suffer from large transmission losses and reduced sensitivity when both core and cladding holes are loaded with the sample liquid (due to a variation of the photonic bandgap induced by the RI change) , the index‐guiding mechanism of light in the core of a side‐channel SC‐PCFs is not considerably altered by the liquid RI because the core RI is still much higher than that of the liquid cladding .…”

Section: Lab In Fibermentioning

confidence: 99%

“…The relevant sensing capabilities of the proposed SERS platform were demonstrated or several case study, such as the detection of R6G with a LOD of 50 fM (1 pM if the liquid sample is infiltrated in the sole side‐channel) , the sialic acid on single cancer cells with a sensitivity of 2 fmol as well as for the accurate monitoring of (lipid peroxidation derived) protein modification in HepG2 cells .…”

Section: Lab In Fibermentioning

confidence: 99%

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Lab on Fiber Technology for biological sensing applications

Vaiano

Carotenuto

Pisco

et al. 2016

Laser & Photonics Reviews

247

155

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This review presents an overview of “Lab on Fiber” technologies and devices with special focus on the design and development of advanced fiber optic nanoprobes for biological applications. Depending on the specific location where functional materials at micro and nanoscale are integrated, “Lab on Fiber Technology” is classified into three main paradigms: Lab on Tip (where functional materials are integrated onto the optical fiber tip), Lab around Fiber (where functional materials are integrated on the outer surface of optical fibers), and Lab in Fiber (where functional materials are integrated within the holey structure of specialty optical fibers). This work reviews the strategies, the main achievements and related devices developed in the “Lab on Fiber” roadmap, discussing perspectives and challenges that lie ahead, with special focus on biological sensing applications.

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“…Over the past decade, photonic crystal fibers (PCFs) have been used as SERS platform to improve the excitation area and make sensors more flexible. The well‐arranged holes that run along the entire length of the fiber could serve as gas or liquid‐chambers leading to an increased interaction area between the guided light and immobilized analyte, resulting in a tremendous enhancement of the Raman signal and thus improved sensitivity . Moreover, increasing the interaction area tends to average the obtained signal and therefore nullify the variation in reproducibility and repeatability as in conventional substrates due to the inherent nanoscale irregularities.…”

Section: Introductionmentioning

confidence: 99%

Development of highly reliable SERS‐active photonic crystal fiber probe and its application in the detection of ovarian cancer biomarker in cyst fluid

Beffara

Perumal

Mahyuddin

et al. 2019

Journal of Biophotonics

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Conventionally Surface‐enhanced Raman spectroscopy (SERS) is realized by adsorbing analytes onto nano‐roughened planar substrate coated with noble metals (silver or gold) or their colloidal nanoparticles (NPs). Nanoscale irregularities in such substrates/NPs could lead to SERS sensors with poor reproducibility and repeatability. Herein, we demonstrate a suspended core photonic crystal fiber (PCF) based SERS sensor with extremely high reproducibility and repeatability in measurement with a relative SD of only 1.5% and 4.6%, respectively, which makes it more reliable than any existing SERS sensor platforms. In addition, our platform could improve the detection sensitivity owing to the increased interaction area between the guided light and the analyte, which is incorporated into the holes that runs along the length of the PCF. Numerical calculation established the significance of the interplay between light coupling efficiency and evanescent field distribution, which could eventually determine the sensitivity and reliability of the developed SERS active‐PCF sensor. As a proof of concept, using this sensor, we demonstrated the detection of haptoglobin, a biomarker for ovarian cancer, contained within the ovarian cyst fluid, which facilitated in differentiating the stages of cancer. We envision that with necessary refinements, this platform could potentially be translated as a next‐generation highly sensitive SERS‐active opto‐fluidic biopsy needle for the detection of biomarkers in body fluids.

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Side-channel photonic crystal fiber for surface enhanced Raman scattering sensing

Cited by 62 publications

References 42 publications

Review of optical fibre probes for enhanced Raman sensing

Review of optical fibre probes for enhanced Raman sensing

Lab on Fiber Technology for biological sensing applications

Development of highly reliable SERS‐active photonic crystal fiber probe and its application in the detection of ovarian cancer biomarker in cyst fluid

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