Side-effects of a Preparation of Vitamin B12

Idiosyncrasy to Aureomycin

“…In spite of the "umbrella" he had developed dermatitis of the hands and feet which had gone on to heavy exfoliation. Other than this, no episode of drug idiosyncrasy had occurred since his first reaction to penicillin in 1944 (Bedford, 1946).…”

“…This-has already been demonstrated with a vitamin B12 streptomyces product (Bedford, 1951). Severe reactions, however uncommon, to aureomycin and the newer "antibiotics" should therefore be anticipated, particularly in those people who are " sensitive " to penicillin.…”

“…It is interesting to speculate on the possible relationship between this patient's idiosyncratic reactions to penicillin and aureomycin. His first episode of BwRnmSH 1429 9~~~~~~~~~~~~~~~~~~~~~~~~M EDICA.L, JOURNAL penicillin dermatitis in 1944 was an acquired sensitivity phenomenon induced by a second course of penicillin 25 days after the first (Bedford, 1946). The second and more severe episode, four weeks before the incident reported above, was expected and guarded against.…”

“…The patient was a healthy but obese man aged 36, whose only known drug idiosyncrasies were to aspirin (with nausea, vomiting, and urticaria) and to penicillin (with eczematous dermatitis) (Bedford, 1946). There was neither a personal nor a family history of asthma, hay-fever, or other "allergic" disorders.…”

New Diluting Fluid for Eosinophil Count

“…penicillin dermatitis in 1944 was an acquired sensitivity phenomenon induced by a second course of penicillin 25 days after the first (Bedford, 1946). The second and more severe episode, four weeks before the incident reported above, was expected and guarded against.…”