Side effects of anesthesia in DM2 as compared to DM1: a comparative retrospective study

Kirzinger, Lukas; Schmidt, Andreas B.; Kornblum, Cornelia; Schneider‐Gold, Christiane; Kreß, Wolfram; Schöser, Benedikt

doi:10.1111/j.1468-1331.2009.02942.x

Cited by 22 publications

(14 citation statements)

References 9 publications

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“…However, 14.9% of the patients complained of worsening of symptoms of DM2 after general anesthesia: a decline in muscular strength, increased myalgia or cramps. This reduced rate of complications in DM2 patients by comparison with DM1 ones was confirmed in another retrospective series of 19 patients anesthetized between 2000 and 2008 .…”

Section: Risk Of Perioperative Complicationsmentioning

confidence: 54%

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Myotonic Dystrophies type 1 and 2: anesthetic care

Veyckemans

Scholtès

2013

Pediatric Anesthesia

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Myotonic dystrophy is classified as one of the myotonic syndromes although myotonia is only a minor characteristic of it. It is, in fact, also a multisystem disease with cardiac, digestive, ocular, and endocrine abnormalities. Two subgroups are currently identified with many similarities: DM1 refers to classic dystrophia myotonica (Steinert disease), while DM2, formerly called proximal myotonic myopathy has a later onset. The congenital form is present only in DM1. The genetic causes of DM1 and 2 are different but end up in a similar way of altering RNAm processing and splicing of other genes. The anesthetic risk is increased in case of DM1 type. This review summarizes current knowledge concerning the pathophysiology and anesthetic management of this disease in children and adults.

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Section: Risk Of Perioperative Complicationsmentioning

confidence: 54%

“…Another retrospective study of 121 DM2 adult patients who had undergone 340 procedures under general anesthesia identified only two severe complications . However, 14.9% of the patients complained of worsening of symptoms of DM2 after general anesthesia: a decline in muscular strength, increased myalgia or cramps.…”

Section: Risk Of Perioperative Complicationsmentioning

confidence: 99%

Myotonic Dystrophies type 1 and 2: anesthetic care

Veyckemans

Scholtès

2013

Pediatric Anesthesia

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“…The pulmonary effects of DM can be significant as shown in a clinical study of 219 patients undergoing surgical procedures by Mathieu; 89% of all complications were pulmonary in nature [1, 5]. Furthermore, patients with DM2 who have less pulmonary involvement have been shown to have less perioperative involvement as compared with DM1 [6]. Both DM1 and DM2 are associated with a high prevalence of sleep-disordered breathing.…”

Section: Pulmonarymentioning

confidence: 99%

“…This is in part from the effect of hypothermia on exacerbating the myotonia and the prolonged effect of muscle relaxants. Although a majority of these symptoms were reversible, a small group of 9 patients had irreversible aggravation of their disease [6]. …”

Section: Musculoskeletalmentioning

confidence: 99%

Anesthetic Considerations in a Patient with Myotonic Dystrophy for Hip Labral Repair

Wang

Ludwin

2017

Case Reports in Anesthesiology

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Myotonic Dystrophy (DM) affects multiple organ systems. Disorders such as hyperthyroidism, progressive musculoskeletal weakness, cardiac dysrhythmias, hypoventilation, and cognitive-behavioral disorders may be present in these patients. Thorough preoperative assessment and anesthetic planning are required to minimize the risk of anesthetic complications. Patients with DM can exhibit exquisite sensitivity to sedatives, neuromuscular blocking agents, and volatile anesthetics, resulting in potential postoperative complications. There is limited literature available on successful anesthetic techniques for the DM patient. We present this case report to add to our current fund of knowledge.

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“…This has proved to be very popular, and many neurologists and clinical neuroscientists have indicated the value of being able quickly to scan a subspecialty area for relevant papers. Therefore we provide here a review of those papers published in 2010 [1–233].…”

mentioning

confidence: 99%