Side Effects of Antibiotics on Immune Response Parameters and their Possible Implications in Antimicrobial Chemotherapy

Gillissen, G

doi:10.1016/s0176-6724(88)80154-8

Cited by 13 publications

(9 citation statements)

References 125 publications

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“…Although the immunomodulatory profile of any drug encompasses its effect on specific and nonspecific immune mediators, owing to the key role of the phagocyte in innate and adaptive defenses and homeostasis, this cell is a major target for immunomodulation. The relevant literature has been periodically reviewed (16,25,113,140,197,199,202,203,205,208,236,330,386,417), reflecting a gradual change from basic, fundamental, and sometimes controversial observations (considered epiphenomena of antibacterial activity) to serious, well-founded tests of the effects of some antibacterial agents in noninfectious diseases.…”

Section: Antibacterial Agents and Phagocytesmentioning

confidence: 99%

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or "Immuno-Fairy Tales"?

Labro¹

2000

Clinical Microbiology Reviews

151

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Section: Antibacterial Agents and Phagocytesmentioning

confidence: 99%

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or "Immuno-Fairy Tales"?

Labro¹

2000

Clinical Microbiology Reviews

151

View full text Add to dashboard Cite

Section: Antibacterial Agents and Phagocytesmentioning

confidence: 99%

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or “Immuno-Fairy Tales”?

Labro

2000

Clin Microbiol Rev

100

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SUMMARY Professional phagocytes (polymorphonuclear neutrophils and monocytes/macrophages) are a main component of the immune system. These cells are involved in both host defenses and various pathological settings characterized by excessive inflammation. Accordingly, they are key targets for immunomodulatory drugs, among which antibacterial agents are promising candidates. The basic and historical concepts of immunomodulation will first be briefly reviewed. Phagocyte complexity will then be unravelled (at least in terms of what we know about the origin, subsets, ambivalent roles, functional capacities, and transductional pathways of this cell and how to explore them). The core subject of this review will be the many possible interactions between antibacterial agents and phagocytes, classified according to demonstrated or potential clinical relevance (e.g., neutropenia, intracellular accumulation, and modulation of bacterial virulence). A detailed review of direct in vitro effects will be provided for the various antibacterial drug families, followed by a discussion of the clinical relevance of these effects in two particular settings: immune deficiency and inflammatory diseases. The prophylactic and therapeutic use of immunomodulatory antibiotics will be considered before conclusions are drawn about the emerging (optimistic) vision of future therapeutic prospects to deal with largely unknown new diseases and new pathogens by using new agents, new techniques, and a better understanding of the phagocyte in particular and the immune system in general.

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“…Due to the fact that certain antibiotics impair phagocytic bactericidal functions, their usage may cause weakened immunity of the patient. The use of antibiotics can lead to a decrease in the capacity of phagocytes for phagocytosis and IKB [ 9 – 11 ]. As was shown by Méhes et al, 2012, the phagocytosis and IKB are impaired in the case of granulocytes (isolated from healthy donors) killing S. aureus strain resistant to vancomycin (heterogeneous vancomycin-intermediate Staphylococcus aureus , hVISA) and methicillin (methicillin-resistant Staphylococcus aureus , MRSA) [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes

Jończyk‐Matysiak

Łusiak-Szelachowska

Kłak

et al. 2015

Journal of Immunology Research

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Intracellular killing of bacteria is one of the fundamental mechanisms against invading pathogens. Impaired intracellular killing of bacteria by phagocytes may be the reason of chronic infections and may be caused by antibiotics or substances that can be produced by some bacteria. Therefore, it was of great practical importance to examine whether phage preparations may influence the process of phagocyte intracellular killing of bacteria. It may be important especially in the case of patients qualified for experimental phage therapy (approximately half of the patients with chronic bacterial infections have their immunity impaired). Our analysis included 51 patients with chronic Gram-negative and Gram-positive bacterial infections treated with phage preparations at the Phage Therapy Unit in Wroclaw. The aim of the study was to investigate the effect of experimental phage therapy on intracellular killing of bacteria by patients' peripheral blood monocytes and polymorphonuclear neutrophils. We observed that phage therapy does not reduce patients' phagocytes' ability to kill bacteria, and it does not affect the activity of phagocytes in patients with initially reduced ability to kill bacteria intracellularly. Our results suggest that experimental phage therapy has no significant adverse effects on the bactericidal properties of phagocytes, which confirms the safety of the therapy.

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Side Effects of Antibiotics on Immune Response Parameters and their Possible Implications in Antimicrobial Chemotherapy

Cited by 13 publications

References 125 publications

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or "Immuno-Fairy Tales"?

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or "Immuno-Fairy Tales"?

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or “Immuno-Fairy Tales”?

The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes

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