Side effects of antidepressants: an overview.

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

“…Current treatment for depression includes drugs such as selective serotonin reuptake inhibitors, tricyclic antidepressants and monoamine oxidase inhibitors. They are effective and tolerated well but noncompliance due to slow action, low response, and plethora of side effects are generally observed [10][11][12][13][14][15][16][17] . Also they inhibit sexual behavior [18] .…”

Novel antidepressant candidate RO-05 modulated glucocorticoid receptors activation and FKBP5 expression in chronic mild stress model in rats

“…However, the antidepressant activity in vivo of RO-05 was not studied yet. Because the current prescribed antidepressants have serious disadvantages such as limitations in efficacy, slow onset, and severe side effects we developed the RO-05 as a new antidepressant candidate which thought to offer advantages over the currently available antidepressants (Khawam et al, 2006;Tuccori et al, 2009;Lam, 2012).…”

Protective role of Broccoli powder against continuous ingestion of Escitalopram antidepressant drug induced hepatotoxicity in Swiss albino male mice

“…Escitalopram antidepressant drug, Broccoli powder, CCl4, Hepatotoxicity increase the levels of other medications metabolized by these enzymes, possibly leading to toxic effects [4], [5], [6] and [7]. Superfoods are excellent source of nutrition that contain large idants, polyphenols, vitamins, and minerals.…”

“…Escitalopram is the most commonly prescribed antidepressant drug comprising 40% of total prescriptions [2] Escitalopram is ntiomer of citalopram [3]. All serotonin reuptake inhibitors are metabolized in liver by cytochrome P450 system for reason they competitively inhibit these hepatic enzyme and increase the levels of other medications metabolized by these enzymes, possibly leading to toxic effects [4], [5], [6] and [7]. Superfoods are excellent source of nutrition that contain large amounts of antioxidants, polyphenols, vitamins, and minerals.…”