Side effects of benoxaprofen.

Abstract

Our results suggest that in the elderly a dose of 600 mg daily is associated with an unacceptable incidence of gastric side effects. It is not clear why elderly patients with osteoarthritis were more prone to gastric side effects than patients with rheumatoid arthritis. Tyson and Glynne reported that in patients over 60 with osteoarthritis benoxaprofen caused more gastric side effects than did ibuprofen, whereas in patients under 60 the reverse was true.4 Compared with other non-steroidal anti-inflammatory agents benoxaprofen has a unique side-effect profile. It remains to be established whether benoxaprofen has the disease-modifying properties that were claimed at the enthusiastic launch of the drug.' 9 We are grateful to Dr A W McKenzie for helpful comments and permission to publish the histological report. We also thank Mrs P K Bramble for help with analysis of data, and Mrs S Palgrave-Moore for secretarial work. Addendum Since the submission of our paper six cases have been reported with hypertrichosis and accelerated nail growth associated with benoxaprofen," one of whom also had milia.22

Photosensibilisation au carprofène (Imadyl^®), un nouvel anti-inflammatoire non stéroïdien

“…1 ), également commercialisé en Suisse depuis peu (Coxigon®; Ely Lilly, Bâ le). Très tôt [1,14], ce médicament a été re connu responsable de réactions de photo sensibilisation avec photoonycholyse chez une proportion variable des patients traités, allant jusqu'à près de 50% [4], Il semble ac tuellement bien établi qu'il s'agit d'une réac tion de photosensibilisation de type photo toxique, comme l'ont montré les travaux ré cents de plusieurs auteurs [2,3,5,9], Fergu son et al [2] ont observé une réaction pho totoxique, lors de phototests, chez tous les patients traités au benoxaprofène. La nature de la photosensibilisation au carprofêne semble différente.…”

Lack of photosensitising potential of tenidap, a novel anti‐rheumatic agent.

“…Similarly, Hindson et al [10] found that wavelengths of 310-330 nm were most effective in producing photosensitisation and pointed out that these wavelengths corresponded to the absorption spectrum of benoxaprofen.…”

“…Their study also showed that Caucasian subjects were most photosensitive, whereas subjects with dark skins and those using broad spectrum sunscreens were more protected. The wavelengths (305-460 nm) selected in the present study were within the range previously shown to induce photosensitivity in rheumatoid arthritis patients and healthy volunteers [10,12]. In addition, the subjects included in the current double-blind study were not dark-skinned and had not been using sunscreens, hence they were not likely to be protected from any possible effects of radiation.…”

Inherent Limitations of the Yellow Card System for the Detection of Unsuspected Adverse Drug Reactions

“…Table 5 shows that all nine were from doctors who had hospital appointments, as determined from the addresses given on the papers and from the Medical Directory of the year in which the papers were published. Further evidence of the importance of hospital clinicians derives from the recent reports concerning the adverse reactions induced by Opren (Goudie et al, 1982;Halsey & Cardoe, 1982;Hindson et al, 1982;Taggart & Alerdice, 1982). Again all were from hospital clinicians, some from the speciality in which the drug would be prescribed (rheumatology) and others from specialities which would be involved in treating the adverse reaction (dermatology, pathology and histopathology).…”