Side Effects of Combined Therapy of Methylprednisolone and Intravenous Immunoglobulin in Guillain-Barré Syndrome

Abstract

Side effects were compared in 9 patients with Guillain-Barré syndrome treated with standard intravenous immunoglobulin (IVIg) only and in 9 treated with combined methylprednisolone and IVIg therapy. Headache occurred in 2 in both groups, indicative that pre-infusion with steroids does not prevent headache. Transient liver function disturbances were present in 2 patients of the former group and in 6 of the latter.

Dermatofibrosarcoma protuberans in a patient with X-linked agammaglobulinaemia

“…Conventionally, tumour immunity has been thought to be cell-mediated and DFSP has been described in the setting of immunodeficiency in two patients with the acquired immunodeficiency syndrome 9 and three patients after renal transplantation, 10 suggesting that T-cell-mediated immunity is likely to play a role in this tumour. However, although there might be a possible link with T cell immunocompromise, overall very few cases of DFSP have been reported in this setting.…”

“…Such lesions may involve a major portion of one gastrointestinal segment and additionally permeate adjacent organs, such as the gastric example with involvement of the oesophageal submucosa, duodenal subserosa and peripancreatic fat, reported by Fernández-Alonso et al 12 Small bowel XAN with microscopic permeation of the adjacent caecum, as seen here, was also noted by Goodman. 10 According to the literature, gastrointestinal XAN most commonly involves the stomach but with significant variations in the reported incidence. A Japanese autopsy study disclosed …”