Side effects of cyproheptadine.

Wortsman, Joshua; Soler, N G; Hirschowitz, Jack

doi:10.1136/bmj.1.6121.1217

Cited by 5 publications

(3 citation statements)

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“…In all other publications, hepatic blood tests were rarely performed. Only two publications reported hepatic blood tests which were normal ( 32 ), or showed isolated high serum alkaline phosphatase levels ( 76 ). Our systematic review of the literature found that hepatic complications with cyproheptadine treatment occurred in 1.4/1,000 patients (5 cases among 3,478 patients), and could be considered as an uncommon AE according to the international classification of medication AEs.…”

Section: Resultsmentioning

confidence: 99%

Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review

et al. 2021

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Objectives: Cyproheptadine is a first-generation H1-antihistamine drug first that was distributed in the 1960s. While its orexigenic effect was observed early, cyprohepatdine is not yet authorized for this indication in all countries today. There is an increasing medical interest and demand for the orexigenic effect of cryoheptadine, especially in children with poor appetite. As cyprohepatdine might be evaluated in future clinical trials, we wanted to assess its safety profile.Methods: Using the French national pharmacovigilance database, we retrospectively analyzed all pediatric and adult reports of adverse effects of cyprohepatdine recorded since its first distribution in France. Next, we performed a systematic review of the literature of cyprohepatdine adverse effects.Results: Since 1985, 93 adverse effects were reported in the French pharmacovigilance database (adults 81.7%, children 18.3%); these were mainly neurological symptoms (n = 38, adults 71%, children 28.9%), and hepatic complications (n = 15, adults 86.7%, children 13.3%). In the literature, the most frequent adverse effect reported was drowsiness in adults or children, and five case reports noted liver complications in adults. We estimated the frequency of hepatic adverse effects at 0.27 to 1.4/1000, regardless of age.Conclusion: Cyprohepatdine can be considered a safe drug. Mild neurological effects appear to be frequent, and hepatotoxicity is uncommon to rare. Randomized controlled trials are needed to evaluate the safety and efficacy of cyprohepatidine before authorization for appetite stimulation, especially in young children as studies at this age are lacking. Possible hepatic complications should be monitored, as very rare cases of liver failure have been reported.

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Section: Resultsmentioning

confidence: 99%

Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review

et al. 2021

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“…However, both MGA and cyproheptadine are known to cause adverse effects. MGA is associated with impotence, deep-vein thrombosis, and gastrointestinal complications, such as diarrhea [30,31], and cyproheptadine has been reported to cause somnolence, hallucinations, tachycardia, and muscle twitching [32,33]. Therefore, efforts to find new treatments that could attenuate anorexia with fewer side effects are needed.…”

Section: Introductionmentioning

confidence: 99%

Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia

Min

Kim

et al. 2022

Pharmaceuticals

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Cisplatin is a well-known chemotherapeutic agent used to treat various types of cancers; however, it can also induce anorexia, which results in reduced food intake, loss of body weight, and lower quality of life. Although drugs such as megestrol acetate and cyproheptadine are used to decrease this severe feeding disorder, they can also induce side effects, such as diarrhea and somnolence, which limit their widespread use. Various types of herbal medicines have long been used to prevent and treat numerous gastrointestinal tract diseases; however, to date, no study has been conducted to analyze and summarize their effects on cisplatin-induced anorexia. In this paper, we analyze 12 animal studies that used either a single herbal medicine extract or mixtures thereof to decrease cisplatin-induced anorexia. Among the herbal medicines, Ginseng Radix was the most used, as it was included in seven studies, whereas both Glycyrrhizae Radix et Rhizoma and Angelicae Gigantis Radix were used in four studies. As for the mechanisms of action, the roles of serotonin and its receptors, cytokines, white blood cells, ghrelin, and leptin were investigated. Based on these results, we suggest that herbal medicines could be considered a useful treatment method for cisplatin-induced anorexia.

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“…Cyproheptadine is a potent serotonine and histamine antagonist (Stone et al,196l), which promotes weight gain under several conditions (Pawlowski, 1975 ;Falk et al, 1985;Halmi et al, 1986). Like other antihistamines, cyproheptadine has been shown to cause drowsiness (Wortsman et al, 1978) but this effect has not been objectively investigated.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of cyproheptadine and DL carnitine on psychomotor performance and memory in healthy volunteers

Hakkou

Jaouen

Iraki

1990

Fundamemntal Clinical Pharma

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This study was performed in order to investigate the extent and severity of cyproheptadine effects on psychomotor performance, mood and memory functions and to compare them to the effects of DL carnitine, another appetite stimulant. Twelve healthy volunteers received 2 doses (at 800 am and 1200 am) of 6 mg cyproheptadine, 1600 mg DL carnitine and placebo on separate days at a weekly intervals. The study followed a double-blind, latin-square design. Assessment of dependent variables was performed 1 h after the first and 1 h and 5 h after the second administration of the drug. On each of these occasions, the following measurements were performed: choice reaction time (CRT), critical flicker fusion (CFF), digit symbol substitution test (DSST), short-term memory (paired words association test), long-term memory (picture test) and 100 mm visual analogue scales of subjective ratings (VAS). Cyproheptadine significantly impaired objective measures (CFF) and subjective ratings both at 1 h and 5 h after the second dosage. Compared with cyproheptadine, DL carnitine induced a slight improvement in psychomotor performance as assessed by CRT. None of the drugs had any effect on memory and on appetite at the doses studied. In conclusion, cyproheptadine at usual doses had a sedative effect, the intensity and duration of which implied a certain risk in performing daytime functions eg when driving, or manipulating machines. DL carnitine had no effect on vigilance.

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Side effects of cyproheptadine.

Cited by 5 publications

References 0 publications

Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review

Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review

Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia

A comparative study of cyproheptadine and DL carnitine on psychomotor performance and memory in healthy volunteers

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