Side Effects of Lithium Therapy and Their Treatment

Wt, Brown

doi:10.1177/070674377602100103

Cited by 7 publications

(1 citation statement)

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“…Since then lithium has been used for a wide variety of other psychiatric and nonpsychiatric uses [8], Concomitant with this increase in usage is a vast reported increase in the number of side effects associated with lithium therapy [15], Brown [3] arbitrarily divided the somatic side effects into three groups -innocuous side effects, side effects indicative of imminent toxicity, and toxic side effects of lithium. The signs of imminent toxicity and the toxic side effects and their relationship to lithium blood level have been well described [10,17].…”

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confidence: 99%

Course and Relationship of Lithium Side Effects to Plasma Lithium Levels

et al. 1981

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49 patients with primary affective disorders maintained on lithium were evaluated over a 6-month course and the pattern of 10 well-known innocuous side effects of lithium therapy was closely evaluated. The patients had significantly more side effects in the 1 st month as opposed to the 4th through 6th months. The difference was statistically significant (with p less than 0.05). There was no difference in plasma lithium levels among individuals having no side effects, 1–2 side effects or 3 or more side effects at any point during the 6-month period.

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confidence: 99%