Side Effects of Non-Steroidal Anti-Inflammatory Drugs: The Experience of Patients with Musculoskeletal Disorders

Teslim, Onigbinde Ayodele

doi:10.11648/j.ajhr.20140204.11

Cited by 15 publications

(10 citation statements)

References 33 publications

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“…Considering the pharmacological interventions to prevent intravenous therapy‐related phlebitis, NSAID gel (Çökmez et al, 2003) was more efficient than heparinoids (Saini et al, 2018). The mechanisms of NSAID gel are already known; it inhibits prostaglandin G/H synthase, or cyclooxygenase, the enzyme that catalyses the transformation of arachidonic acid to prostaglandins and thromboxanes responsible for the inflammatory response (Teslim, 2014). In contrast, in addition to the anti‐inflammatory properties, sesame oil has anti‐mutagenic, anti‐oxidant, anti‐cardio and anti‐pyretic protective effects as well as anti‐nociceptive properties and is widely used in Iranian and Taiwanese traditional medicine (Bigdeli Shamloo et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

Goulart

Custódio

Vasques

et al. 2020

Journal of Clinical Nursing

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Aims and objectives To evaluate the effectiveness of topical interventions in the prevention or treatment of intravenous therapy‐related phlebitis. Background Phlebitis is a severe inflammatory reaction that can be caused by intravenous therapy with hyperosmolar drugs. Although a variety of interventions are performed in several different countries, the most efficient method is yet to be established. Design A systematic review of randomised controlled trials (RCTs) was conducted. Methods Following the PRISMA checklist, we conducted a literature search using seven different databases using an individual strategy adapted for each. Studies in which any topical intervention was applied to prevent or treat intravenous therapy‐related phlebitis which were published between 1998 and 2019 were analysed. Results Data were collected of 13 RCTs, which in total collected data from 2,015 patients during hospital treatments with different types of intravenous therapies, such as fluid replacement, antibiotics, chemotherapy and antiarrhythmic drugs. The effectiveness of different topical interventions such as the application of nonsteroidal anti‐inflammatory drugs, Sesame indicum oil, heparin sodium formulations, Chamomilla recutita tea and ointment, and Rosmarinus officinalis ointment were identified. Relevance to Clinical Practice Although the studies suggest a potential to use phytotherapy agents as topical interventions, pharmaceutical preparations, main substrate, and pharmaceutical or phytotherapeutic origins are very different between studies. There are insufficient data to build a solid conclusion that lead us to recommend a specific topical intervention in the prevention or treatment of intravenous therapy‐related phlebitis.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

Goulart

Custódio

Vasques

et al. 2020

Journal of Clinical Nursing

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“…The DHP letter with the best awareness amongst all health workers was; diclofenac and the risk of cardiovascular events 213 (60.00%), followed azithromycin and cardiovascular risks 212 (59.72%), with the least being the use of codeine for analgesia in children and adolescents, 132 (37.18%). This could be explained by the fact that of the medicines, diclofenac and azithromycin are the most used analgesic and antibacterial agent, respectively; hence, the interest of the health workers in these safety issues (Van Boeckel et al, 2014;CDDEP, 2015;Desalegn, 2013;Teslim et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of dear healthcare professional letters as a risk minimization tool in Ghana

Sabblah¹,

Darko²,

Asamoa-Amoakohene³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Dear Healthcare Professional (DHP) letter is a risk minimization tool used to inform health workers about new and emerging safety information during the marketing period of medicinal products. DHP letters in some cases may not be effective because targeted audience may not be aware of these letters or even understand them. The objectives of this study were to assess the effectiveness and relevance of DHP letters as effective risk minimization tool and to seek opinion of health workers about the most effective way of communicating safety information. A descriptive correlational study of 913 health workers selected by convenient sampling through face-to-face interviews from Apr. to June, 2014 was conducted, with a response rate of 83.15%. The data was analyzed using descriptive analysis and Pearson-chi square test (χ 2 ) with STATA version 13. A p-value of < 0.05 was considered significant during the analysis. Of the 913 respondents only 350 (38.34%) were aware of at least one of the letters distributed in 2013 and 314 (89.71%) out of these admitted that these letters have influenced their way of prescribing, dispensing and administering the medicines involved. One hundred and ninety-two (54.82%) of the respondents rated the level of understanding of the language used as good and there was no significant difference in the health workers rating of the language used in the letters (p=0.40). Health workers suggested electronic methods such as short messaging service to their mobile phones 56.81% (438), e-mail 91 (85.85%) and posting the letters on the Food and Drugs Authority's website 26.85% (207). The results suggest that DHP letters issued by the Food and Drugs Authority (FDA) are effective in changing behavior of those who receive them but they are received late or not at all. The FDA should therefore explore other means of communicating safety information such as electronic means as suggested by the health workers.

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“…Non-steroidal anti-inflammatory drugs (NSAIDs) are of choice for acute pain management in musculoskeletal disorders (MSDs) but they are not without side effects [21]. NSAIDs are drugs of choice for acute pain management that may characterize musculoskeletal disorders including low back pain [22,23].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Relationship between Analgesic and Alcohol Consumption, Smoking Habit and Occurrence of Lowback Pain amongst Craftsmen in a South-East Nigerian Community

Ayeni¹

2014

AJHR

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Low back pain (LBP) is a major cause of disability with high economic and public health repercussions. The main objectives of this study were to determine the prevalence and relationship between analgesic and alcohol consumption, smoking and occurrence of lowback pain amongst craftsmen in Owerri, a South-East Nigerian community. A structured questionnaire was used to collect data on lifestyle and low back pain of 500 craftsmen. The data was analyzed using descriptive statistics of mean, percentage, frequency and inferential statistics of chi square; and multiple regressions. The result showed that the point prevalence for LBP was 34%. The 3-month, 12-month and life time prevalence of LBP were 35.4% 57.4% and 69.0% respectively. Habits of analgesic consumption (OR = 5.51; CI = 1.07 -4.29; p = 0.048) and alcohol consumption (OR=2.53, CI=1.47-4.38, p<0.001) had significant association with low back pain. We concluded that the point prevalence for low back pain was 34%. Also, LBP was associated with some selected lifestyle factors.

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Side Effects of Non-Steroidal Anti-Inflammatory Drugs: The Experience of Patients with Musculoskeletal Disorders

Cited by 15 publications

References 33 publications

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

The effectiveness of dear healthcare professional letters as a risk minimization tool in Ghana

Prevalence and Relationship between Analgesic and Alcohol Consumption, Smoking Habit and Occurrence of Lowback Pain amongst Craftsmen in a South-East Nigerian Community

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