Side effects of opioids during short-term administration: effect of age, gender, and race

Cepeda, M. Soledad

doi:10.1016/s0009-9236(03)00152-8

Cited by 311 publications

(223 citation statements)

References 59 publications

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“…Unfortunately, many complications after TKA may be associated with pain management strategies themselves. Opioid analgesics, including intravenous, patient-controlled, and oral, have been a standard modality for postoperative pain management but are also associated with increased risk of nausea, pruritus, vomiting, respiratory depression, prolonged ileus, and cognitive dysfunction [18,64,85]. Regional pain control techniques such as femoral nerve blockade may limit exposure to opioid-related adverse events but may lead to other complications such as quadriceps weakness, neuropathy, and postoperative falls [8,75].…”

Section: Introductionmentioning

confidence: 99%

No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

Barrington

Emerson

Lovald

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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Background Opioid analgesics have been a standard modality for postoperative pain management after total knee arthroplasty (TKA) but are also associated with increased risk of nausea, pruritus, vomiting, respiratory depression, prolonged ileus, and cognitive dysfunction.There is still a need for a method of anesthesia that can deliver effective long-term postoperative pain relief without incurring the high cost and health burden of opioids and nerve blocks. Questions/purposes (1) Is liposomal bupivacaine-based periarticular injection (PAI) more effective than morphinebased spinal anesthesia or ropivacaine-based PAI in

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Section: Introductionmentioning

confidence: 99%

No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

Barrington

Emerson

Lovald

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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“…It should be noted that findings from several studies suggest that sex (19)(20)(21)(22)(23)(24) and ethnic (25-28) differences exist in the prevalence and severity of side effects. For example, women were found to be more sensitive to the respiratory effects of morphine (22).…”

Section: Discussionmentioning

confidence: 99%

Differences in the Prevalence and Severity of Side Effects Based on Type of Analgesic Prescription in Patients with Chronic Cancer Pain

Villars

Dodd

West

et al. 2007

Journal of Pain and Symptom Management

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An understanding of the relationship between the type of analgesic prescription and the prevalence and severity of side effects is crucial in making appropriate treatment decisions. The purposes of this study were: to determine if there were differences in the prevalence of side effects among four different types of analgesic prescriptions (i.e., no opioid, only an as needed (PRN) opioid, only an around-the-clock (ATC) opioid, or an ATC + PRN opioid); to determine if there were differences in the severity of side effects among the four prescriptions groups; and to determine the relationships between the total dose of opioid analgesic medication prescribed and taken and the severity of side effects. As part of a larger study, 174 cancer patients with bone metastasis reported their analgesic use and the prevalence and severity of eleven side effects. Significant differences (P < 0.05) were found in prevalence rates for seven of the side effects among the four prescription groups. The highest prevalence rates were found in the only ATC and ATC + PRN groups. Significant differences were found in the severity scores for five of the side effects, with the highest severity scores reported by patients in the only ATC and ATC + PRN groups. Significant positive correlations were found between the severity of six of the side effects and the total dose of opioid prescribed and taken. Risk factors for analgesic-induced side effects are ATC and ATC + PRN prescription types and higher doses of opioid analgesics.

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“…Patients with extreme of age: Limited organ reserve-risk of over-sedation [65][66][67] . Paediatric consideration: The choice and selection of agent for pediatric procedural sedation differ slightly.…”

Section: Benzodiazepines (Bzd)mentioning

confidence: 99%

Changing Trends in Dental Procedural Sedation

Upadhyay¹,

Tellicherry²,

Samant³

et al. 2016

JAS

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Side effects of opioids during short-term administration: effect of age, gender, and race

Abstract: Meperidine produced fewer side effects than morphine during short-term use. The risk of respiratory depression increases substantially after 60 years of age. Women have nausea and vomiting more often than men. The effect of race deserves further investigation.

Cited by 311 publications

References 59 publications

No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

Differences in the Prevalence and Severity of Side Effects Based on Type of Analgesic Prescription in Patients with Chronic Cancer Pain

Changing Trends in Dental Procedural Sedation

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