Side Effects to Systemic Glucocorticoid Therapy in Dogs Under Primary Veterinary Care in the UK

Elkholly, Doaa A.; Brodbelt, David; Church, David; Pelligand, Ludovic; Mwacalimba, Kennedy; Wright, Andrea; O’Neill, Dan G.

doi:10.3389/fvets.2020.00515

Cited by 41 publications

(55 citation statements)

References 29 publications

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“…It was not recorded why these dogs did not receive assisted enteral feeding; however, the decision to not place an enteral feeding tube in dogs with PLE with decreased appetite might occur for a number of reasons. For example, owner preference, increased anesthesia time, the assumption that appetite will improve following glucocorticoid treatment, 30 complicating factors associated with the disease such as coagulopathies 31 and increased healing time due to hypoalbuminemia. 32 In our study, the complication rate for dogs with assisted enteral feeding was 14%, compared to 43.1% with esophagostomy tubes.…”

Section: Discussionmentioning

confidence: 99%

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein‐losing enteropathy

Economu

Chang

Priestnall

et al. 2021

Veterinary Internal Medicne

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Background The effect of assisted enteral feeding on treatment outcome in dogs with protein‐losing enteropathy (PLE) is unknown. Objectives To determine if dogs with inflammatory PLE that had an enteral feeding tube placed had better outcome vs dogs with inflammatory PLE without a feeding tube. Animals Fifty‐seven dogs with inflammatory PLE. Methods A retrospective study at a UK referral hospital identified dogs with inflammatory PLE using a standard diagnostic criterion. Positive outcome was defined as survival greater than 6 months or death unrelated to PLE and negative outcome as death related to PLE within 6 months of diagnosis. Several variables were assessed to identify factors for positive outcome using logistic regression. Results Thirty‐five (61%) and 22 (39%) dogs had a positive and negative outcome at 6 months, respectively. Of the 21 dogs that had a feeding tube placed within 5 days of gastrointestinal biopsy, 16 (76%) had a positive outcome and 5 (24%) had a negative outcome. Dogs treated with dietary treatment alone (P = .002) and dogs with an enteral feeding tube (P = .006) were significantly associated with a positive outcome. When stratified by treatment, assisted enteral feeding was significantly associated with a positive outcome in dogs treated with concurrent immunosuppressive treatment (P = .006), but there was insufficient data to evaluate dogs treated with dietary treatment alone. Conclusions and Clinical Importance Assisted enteral feeding in dogs with inflammatory PLE could be associated with improved treatment outcome, especially in those receiving immunosuppressive treatment, and should be considered in the treatment plan of these dogs.

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Section: Discussionmentioning

confidence: 99%

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein‐losing enteropathy

Economu

Chang

Priestnall

et al. 2021

Veterinary Internal Medicne

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“…The wide use of corticosteroids in veterinary medicine and the scarce reporting of behavioural changes compared with other more frequently reported side effects might indicate that either these changes are rare/eligible, or that they were not considered to be related to the treatment and therefore not reported to the clinician [ 16 ]. Another possible explanation could be that either owners do not feel they need to report signs of changes in their dogs’ behaviours to their vet or vets do not inquire about their patients’ behaviour.…”

Section: Introductionmentioning

confidence: 99%

Psycho-Behavioural Changes in Dogs Treated with Corticosteroids: A Clinical Behaviour Perspective

Notari

Kirton

Mills

2022

Animals

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Arousal and distress are often important factors in problematic behaviours, and endogenous corticosteroids are important mediators in the associated stress responses. Exogenous corticosteroid treatments have been reported to change behaviour in human patients and laboratory animals, with similar changes also noted in pet dogs. These behaviours not only potentially adversely impact the welfare of the dogs, but also the quality of life of their owners. Indeed, corticosteroids can bias sensitivity towards aversion in dogs. A decrease in behaviours associated with positive affective states, such as play and exploratory behaviours, together with an increase in aggression and barking have also been described in dogs. According to the available literature, human patients with pre-existing psychiatric disorders are more at risk of developing behavioural side effects due to corticosteroid treatments. It is reasonable to consider that the same may happen in dogs with pre-existing behavioural problems. In this paper, the possible behavioural side effects of exogenous corticosteroids are summarised to help inform and support veterinarians prescribing these drugs.

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“…These include dermatologic diseases in which anti‐inflammatory effects are beneficial in providing patient comfort, as well as immune‐mediated diseases in which higher doses are used for immunosuppression 3,4 . Glucocorticoids, however, have adverse effects, including polyphagia, muscle wasting, polyuria, and polydipsia 1,3,5,6 . Proposed mechanisms for the polyuria and polydipsia induced by glucocorticoids include primary polydipsia and antagonism of the antidiuretic hormone (ADH) receptor 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Glucocorticoids, including prednisolone, are used in the treatment of many diseases in veterinary medicine. 1 , 2 , 3 These include dermatologic diseases in which anti‐inflammatory effects are beneficial in providing patient comfort, as well as immune‐mediated diseases in which higher doses are used for immunosuppression. 3 , 4 Glucocorticoids, however, have adverse effects, including polyphagia, muscle wasting, polyuria, and polydipsia.…”

Section: Introductionmentioning

confidence: 99%

“…3 , 4 Glucocorticoids, however, have adverse effects, including polyphagia, muscle wasting, polyuria, and polydipsia. 1 , 3 , 5 , 6 Proposed mechanisms for the polyuria and polydipsia induced by glucocorticoids include primary polydipsia and antagonism of the antidiuretic hormone (ADH) receptor. 7 Polyuria and polydipsia may become a quality of life issue for both owners and their pets.…”

Section: Introductionmentioning

confidence: 99%

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Effects of desmopressin acetate administration in healthy dogs receiving prednisolone

Galati

Archer

Jolly

et al. 2021

Veterinary Internal Medicne

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Background Glucocorticoids are used for a variety of purposes in veterinary medicine but often are associated with clinically important adverse effects. Polyuria and polydipsia are the most frustrating adverse effects noted by owners. Objective To determine whether administration of desmopressin ameliorates polyuria and polydipsia associated with prednisolone administration. Animals Seven healthy adult Walker Hounds. Methods Prospective hypothesis testing study. Daily water intake and urine specific gravity (USG) were measured in dogs under 4 separate sequential conditions: no medications (C), prednisolone only (P), prednisolone and desmopressin (PD), and prednisolone after discontinuation of desmopressin (PAD). Results When compared to baseline, 6 of 7 dogs became polydipsic after administration of prednisolone (0.5 mg/kg PO q12h). When desmopressin (5 μg/dog SC q12h) was administered to dogs receiving prednisolone, significant decreases in water intake and serum sodium concentration occurred, and USG increased significantly. Conclusions and Clinical Importance Administration of desmopressin to dogs receiving prednisolone significantly decreased water intake and serum sodium concentration, and increased USG. Our results suggest that, in some dogs, desmopressin ameliorates the most important adverse effect of prednisolone noted by owners, but that hyponatremia is an important complication associated with desmopressin use.

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Side Effects to Systemic Glucocorticoid Therapy in Dogs Under Primary Veterinary Care in the UK

Cited by 41 publications

References 29 publications

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein‐losing enteropathy

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein‐losing enteropathy

Psycho-Behavioural Changes in Dogs Treated with Corticosteroids: A Clinical Behaviour Perspective

Effects of desmopressin acetate administration in healthy dogs receiving prednisolone

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