Side-to-side nerve bridges reduce muscle atrophy after peripheral nerve injury in a rodent model

Shea, Jill E.; Garlick, Jared W.; Salama, Mohamed E.; Mendenhall, Shaun D.; Moran, Linh A.; Agarwal, Jayant P.

doi:10.1016/j.jss.2013.10.023

Cited by 21 publications

(21 citation statements)

References 21 publications

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“…In addition, encouraging results on the application of side-to-side coaptation as a complementary technique have been presented by Arm [4] and Shea [50], who observed reduced muscle atrophy with a side-to-side nerve bridge combined with traditional end-to-end neurorrhaphy.…”

Section: Discussionmentioning

confidence: 99%

Collateral sprouting axons of end-to-side nerve coaptation in the avulsion of ventral branches of the C5-C6 spinal nerves in the brachial plexus

Reichert

Kiełbowicz²,

Dzięgiel³

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Collateral sprouting axons of end-to-side nerve coaptation in the avulsion of ventral branches of the C5-C6 spinal nerves in the brachial plexus

Reichert

Kiełbowicz²,

Dzięgiel³

et al. 2015

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“…However, a prerequisite for this technique is the appropriate anatomical structure that allows the approximation of two parallel nerve trunks. For cases not allowing this, various other techniques have been developed to connect parallel nerves to the side-to-side bridge technique with nerve grafts [14, 20, 36] or synthetic conduits [26]. The obvious weaknesses of the present study are the differences in the regeneration capacity as well as the differences of the nerves between rodents and humans.…”

Section: Discussionmentioning

confidence: 99%

Protective distal side-to-side neurorrhaphy in proximal nerve injury—an experimental study with rats

et al. 2019

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BackgroundSide-to-side neurorrhaphy may protect the denervated end organ and preserve the initial connection with proximal stump. We examined the effect of protective side-to-side anastomosis on nerve and end organ regeneration in proximal nerve injury model.MethodsThe left common peroneal nerve of 24 Sprague Dawley rats was proximally transected. In groups B and C, side-to-side neurorrhaphy was performed distally between the peroneal and tibial nerves without (group B) and with (group C) partial donor nerve axotomy inside the epineural window. Group A served as an unprotected control. After 26 weeks, the proximal transection was repaired with end-to-end neurorrhaphy on all animals. Regeneration was followed during 12 weeks with the walk track analysis. Morphometric studies and wet muscle mass calculations were conducted at the end of the follow-up period.ResultsThe results of the walk track analysis were significantly better in groups B and C compared to group A. Groups B and C showed significantly higher wet mass ratios of the tibialis anterior and extensor digitorum longus muscle compared to group A. Group C showed significantly higher morphometric values compared to group A. Group B reached higher values of the fibre count, fibre density, and percentage of the fibre area compared to group A.ConclusionsProtective distal side-to-side neurorrhaphy reduced muscle atrophy and had an improving effect on the morphometric studies and walk track analysis. Distal side-to-side neurorrhaphy does not prevent the regenerating axons to grow from the proximal stump to achieve distal nerve stump.

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“…Besides comparable repair results with ETS neurorrhaphy, 5 STS neurorrhaphy can be combined with other reconstructive techniques as it leaves the end of the distal nerve stump available. Although STS repair alone may not have enough regenerative potential for sufficient functional recovery, it may have potential to reduce muscle atrophy 20,21 and maintain a growth-supportive atmosphere for further reconstructions. Thus, we aim to study STS neurorrhaphy as part of the treatment of proximal nerve injuries.…”

Section: Discussionmentioning

confidence: 99%

Effect of Axonal Trauma on Nerve Regeneration in Side-to-side Neurorrhaphy: An Experimental Study

Rönkkö

Göransson

Taskinen

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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Background:Side-to-side (STS) neurorrhaphy can be performed distally to ensure timely end-organ innervation. It leaves the distal end of the injured nerve intact for further reconstruction. Despite encouraging clinical results, only few experimental studies have been published to enhance the regeneration results of the procedure. We examined the influence of different size epineural windows and degree of axonal injury of STS repair on nerve regeneration and donor nerve morbidity.Methods:Three clinically relevant repair techniques of the transected common peroneal nerve (CPN) were compared. Group A: 10-mm long epineural STS windows; group B: 2-mm long windows and partial axotomy to the donor tibial nerve; and group C: 2-mm long windows with axotomies to both nerves. Regeneration was followed by the walk track analysis, nerve morphometry, histology, and wet muscle mass calculations.Results:The results of the walk track analysis were significantly better in groups B and C compared with group A. The nerve fiber count, total fiber area, fiber density, and percentage of the fiber area values of CPN of the group C were significantly higher when compared with group A. The wet mass ratio of the CPN-innervated anterior tibial muscle was significantly higher in group C compared with group A. The wet mass ratio of the tibial nerve–innervated gastrocnemial muscle was higher in group A compared with the other groups.Conclusions:All three variations of the STS repair technique showed nerve regeneration. Deliberate donor nerve axotomy enhanced nerve regeneration. A larger epineural window did not compensate the effect of axonal trauma on nerve regeneration.

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Side-to-side nerve bridges reduce muscle atrophy after peripheral nerve injury in a rodent model

Cited by 21 publications

References 21 publications

Collateral sprouting axons of end-to-side nerve coaptation in the avulsion of ventral branches of the C5-C6 spinal nerves in the brachial plexus

Collateral sprouting axons of end-to-side nerve coaptation in the avulsion of ventral branches of the C5-C6 spinal nerves in the brachial plexus

Protective distal side-to-side neurorrhaphy in proximal nerve injury—an experimental study with rats

Effect of Axonal Trauma on Nerve Regeneration in Side-to-side Neurorrhaphy: An Experimental Study

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