Siderophore Production by
            <i>Pseudomonas stutzeri</i>
            under Aerobic and Anaerobic Conditions

Essén, Sofia; Johnsson, Anna; Bylund, Dan; Pedersen, Karsten; Lundström, Ulla

doi:10.1128/aem.00072-07

Cited by 57 publications

(38 citation statements)

References 29 publications

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“…Under aerobic condition, Pseudomonas stutzeri CCUG 36651 was reported to produce four ferrioxamine siderophores. In contrast, none of these ferrioxamines siderophores were found under anaerobic conditions (Essen et al 2007). Siderophore first binds with iron (Fe +3 ) tightly and then the siderophore-iron complex moves into the cell through the cell membrane using the specific siderophore receptors.…”

Section: Introductionmentioning

confidence: 96%

“…Generally, most of the aerobic and facultative anaerobic bacteria were found to produce siderophore under iron stress condition (Neilands 1995). It has been reported that a facultative aerobic bacterium Pseudomonas stutzeri CCUG 36651 can produce siderophores in both aerobic and anaerobic conditions, but the siderophore produced in aerobic condition varies from siderophores produced in anaerobic condition (Essen et al 2007). Under aerobic condition, Pseudomonas stutzeri CCUG 36651 was reported to produce four ferrioxamine siderophores.…”

Section: Introductionmentioning

confidence: 98%

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Microbial siderophores and their potential applications: a review

Saha

Sarkar

et al. 2015

Environ Sci Pollut Res

597

278

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Siderophores are small organic molecules produced by microorganisms under iron-limiting conditions which enhance the uptake of iron to the microorganisms. In environment, the ferric form of iron is insoluble and inaccessible at physiological pH (7.35-7.40). Under this condition, microorganisms synthesize siderophores which have high affinity for ferric iron. These ferric iron-siderophore complexes are then transported to cytosol. In cytosol, the ferric iron gets reduced into ferrous iron and becomes accessible to microorganism. In recent times, siderophores have drawn much attention due to its potential roles in different fields. Siderophores have application in microbial ecology to enhance the growth of several unculturable microorganisms and can alter the microbial communities. In the field of agriculture, different types of siderophores promote the growth of several plant species and increase their yield by enhancing the Fe uptake to plants. Siderophores acts as a potential biocontrol agent against harmful phyto-pathogens and holds the ability to substitute hazardous pesticides. Heavy-metal-contaminated samples can be detoxified by applying siderophores, which explicate its role in bioremediation. Siderophores can detect the iron content in different environments, exhibiting its role as a biosensor. In the medical field, siderophore uses the "Trojan horse strategy" to form complexes with antibiotics and helps in the selective delivery of antibiotics to the antibiotic-resistant bacteria. Certain iron overload diseases for example sickle cell anemia can be treated with the help of siderophores. Other medical applications of siderophores include antimalarial activity, removal of transuranic elements from the body, and anticancer activity. The aim of this review is to discuss the important roles and applications of siderophores in different sectors including ecology, agriculture, bioremediation, biosensor, and medicine.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

Microbial siderophores and their potential applications: a review

Saha

Sarkar

et al. 2015

Environ Sci Pollut Res

597

278

View full text Add to dashboard Cite

show abstract

“…could produce high concentrations (9 nM) of ferrioxamine B and (13 nM) of ferrioxamine G, respectively. However, Essén et al (2007) showed that P. stutzeri could produce ferrioxamine E as the main siderophore together with ferrioxamine G. In the present study, the isolated N. tenerifensis and N. farcinica produced all the ferrioxamine types except ferrioxamines E. Moreover, both isolates were characterized by high concentrations of ferrioxamine D (17 nM) for N. tenerifensis and (15 nM) for N. farcinica.…”

Section: Pseudomonas)mentioning

confidence: 73%

Siderophore Production by Microorganisms Isolated From a Podzol Soil Profile

Ahmed

Holmström

2014

Geomicrobiology Journal

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Siderophore producing bacteria/actinobacteria and fungi were isolated from O-(organic), E-(eluvial), B-(upper illuvial), and C-(parent material) horizons of podzol soil. Siderophores were isolated and hydroxamate type siderophores were detected and quantitated by high-performance liquid chromatography coupled to electrospray ionization mass spectrometry. The molecular identification of siderophore producing isolates showed that there was a high diversity of fungal and bacterial/actinobacterial species throughout the soil profile. The isolated bacteria/actinobacteria showed different abilities in the production of ferrioxamines (E, B, G and D). Moreover, the isolated fungal species showed great variety in the production of ferrichromes, coprogens and fusarinines.

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“…Furthermore, Kobayakawa and Kodani detected by high-performance liquid chromatography (HPLC) the production of desferrioxamines in 78% of their Streptomyces collection (61). Desferrioxamines are also produced by other actinomycetes and some Gram-negative bacteria (62,63).…”

Section: Discussionmentioning

confidence: 99%

Pseudomonas fluorescens Pirates both Ferrioxamine and Ferricoelichelin Siderophores from Streptomyces ambofaciens

Galet

Deveau

Hôtel

et al. 2015

Appl Environ Microbiol

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Iron is essential in many biological processes. However, its bioavailability is reduced in aerobic environments, such as soil. To overcome this limitation, microorganisms have developed different strategies, such as iron chelation by siderophores. Some bacteria have even gained the ability to detect and utilize xenosiderophores, i.e., siderophores produced by other organisms. We illustrate an example of such an interaction between two soil bacteria, Pseudomonas fluorescens strain BBc6R8 and Streptomyces ambofaciens ATCC 23877, which produce the siderophores pyoverdine and enantiopyochelin and the siderophores desferrioxamines B and E and coelichelin, respectively. During pairwise cultures on iron-limiting agar medium, no induction of siderophore synthesis by P. fluorescens BBc6R8 was observed in the presence of S. ambofaciens ATCC 23877. Cocultures with a Streptomyces mutant strain that produced either coelichelin or desferrioxamines, as well as culture in a medium supplemented with desferrioxamine B, resulted in the absence of pyoverdine production; however, culture with a double mutant deficient in desferrioxamines and coelichelin production did not. This strongly suggests that P. fluorescens BBbc6R8 utilizes the ferrioxamines and ferricoelichelin produced by S. ambofaciens as xenosiderophores and therefore no longer activates the production of its own siderophores. A screening of a library of P. fluorescens BBc6R8 mutants highlighted the involvement of the TonB-dependent receptor FoxA in this process: the expression of foxA and genes involved in the regulation of its biosynthesis was induced in the presence of S. ambofaciens. In a competitive environment, such as soil, siderophore piracy could well be one of the driving forces that determine the outcome of microbial competition. Bacteria detect, assimilate, and integrate different environmental signals in order to better adapt to their habitat and cope with changes in environmental conditions. Multiple signaling pathways allow them to communicate with each other within the same species or between different species (1). This can be achieved through the production and detection of diffusible molecules in the environment. In response to these interactions, the microorganisms have developed complex metabolic and physiological responses. One of the essential environmental factors vital for organisms is iron. It plays an essential role in many biological processes, such as DNA synthesis, respiration, and photosynthesis. Iron can adopt two different ionic forms, Fe 2ϩ and Fe 3ϩ . This property makes it an important player in the oxidation-reduction reactions in the cell. However, while iron is an abundant element on earth, its bioavailability is reduced in aerobic environments, such as soil. Ferric iron (Fe 3ϩ ) forms insoluble ferric hydroxides (with a solubility product of ϳ10 Ϫ39 ) in the presence of oxygen (2-4). Therefore, iron is a limiting factor for the growth of microorganisms.To overcome the limitation of iron bioavailability, aerobic bacteria have develop...

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Siderophore Production by Pseudomonas stutzeri under Aerobic and Anaerobic Conditions

Cited by 57 publications

References 29 publications

Microbial siderophores and their potential applications: a review

Microbial siderophores and their potential applications: a review

Siderophore Production by Microorganisms Isolated From a Podzol Soil Profile

Pseudomonas fluorescens Pirates both Ferrioxamine and Ferricoelichelin Siderophores from Streptomyces ambofaciens

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